Evidence map›Paper›PMID 38758406›Full record

ArticleArchives of toxicology2024

Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics.

Rui Wang, Wei Lang, Qian Xue, Le Zhang, Yunzhu Xujia, Chaofan Wang, Xin Fang, Shidi Gao, Li Guo

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In one paragraph

Article in Archives of toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rui WangDepartment of Toxicology, School of Public Health, Jilin University, Changchun, 130021, Jilin Province, China.
Wei LangDepartment of Gynecology III, Changchun Obstetrics-Gynecology Hospital, Changchun, 130042, Jilin Province, China.
Qian XueDepartment of Toxicology, School of Public Health, Jilin University, Changchun, 130021, Jilin Province, China.
Le ZhangDepartment of Toxicology, School of Public Health, Jilin University, Changchun, 130021, Jilin Province, China.
Yunzhu XujiaDepartment of Toxicology, School of Public Health, Jilin University, Changchun, 130021, Jilin Province, China.
Chaofan WangDepartment of Toxicology, School of Public Health, Jilin University, Changchun, 130021, Jilin Province, China.
Xin FangDepartment of Toxicology, School of Public Health, Jilin University, Changchun, 130021, Jilin Province, China.
Shidi GaoDepartment of Toxicology, School of Public Health, Jilin University, Changchun, 130021, Jilin Province, China.
Li GuoDepartment of Toxicology, School of Public Health, Jilin University, Changchun, 130021, Jilin Province, China. gli@jlu.edu.cn.ORCID 0000-0003-0575-6715

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial carcinoma is one of most common malignant tumors in women, and ferroptosis is closely related to the development and treatment of endometrial carcinoma. The aim of this study was to screen ferroptosis-related genes associated with endometrial carcinoma and predict targeted drugs through bioinformatics. 761 differentially expressed genes were obtained by the dataset GSE63678 from the GEO database, and most of the genes were enriched in the KEGG_CELL_CYCLE and KEGG_OOCYTE_MEIOSIS signaling pathways. 22 ferroptosis-differentially expressed genes were obtained by intersection with the FerrDb database. These genes were involved in biological processes including macromolecular complex assembly and others, and involved in signal pathways including glutathione metabolism, p53 signaling pathway and others. CDKN2A, IDH1, NRAS, TFRC and GOT1 were obtained as hub genes by PPI network analysis. GEPIA showed that CDKN2A, IDH1, NRAS and TFRC were significantly expressed in endometrial carcinoma. Immunohistochemical results showed that CDKN2A, NRAS and TFRC were significantly expressed in endometrial carcinoma clinical tissue samples. The ROC constructed by TCGA database showed that CDKN2A, NRAS and TFRC had significant value in the diagnosis of endometrial carcinoma, and all had prognostic efficacy. 136,572-09-3 BOSS and others were identified as potential targeted drugs for endometrial carcinoma targeting ferroptosis. Our study has shown that ferroptosis-related genes CDKN2A, NRAS and TFRC are diagnostic markers of endometrial carcinoma, and 136,572-09-3 BOSS, methyprylon BOSS, daunorubicin CTD 00005752, nitroglycerin BOSS and dUTP BOSS, IRON BOSS, Imatinib mesylate BOSS, 2-Butanone BOSS, water BOSS, and L-thyroxine BOSS may be potential therapeutic drugs.

Indexed as

Computational BiologyEndometrial NeoplasmsFerroptosisAntigens, CDAntineoplastic AgentsBiomarkers, TumorCyclin-Dependent Kinase Inhibitor p16Databases, GeneticFemaleGene Expression Regulation, NeoplasticGTP PhosphohydrolasesHumansMembrane ProteinsProtein Interaction MapsReceptors, TransferrinAntigens, CDAntineoplastic AgentsBiomarkers, TumorCD71 antigenCyclin-Dependent Kinase Inhibitor p16GTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanReceptors, TransferrinBioinformaticsDifferentially expressed genesDrug predictionEndometrial carcinomaFerroptosis

Identifiers

PMID38758406

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.