Evidence map›Paper›PMID 38758370›Full record

Observational studyEuropean journal of nuclear medicine and molecular imaging2024

Assessment of cerebral drug occupancy in humans using a single PET-scan: A [

Maja R Marstrand-Joergensen, Gjertrud L Laurell, Susan Herrmann, Arafat Nasser, Annette Johansen, Anton Lund, Thomas L Andersen, Gitte M Knudsen, Lars H Pinborg

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05450822 (The BrainDrugs-Epilepsy Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05450822 recruitingnot on this map

The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy

TypeobservationalSponsorGitte Moos KnudsenRan2022 to 2031Enrolled550ConditionsEpilepsyArmsLevetiracetam, Levetiracetam Tablets, Lamotrigine tablet
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maja R Marstrand-JoergensenEpilepsy Clinic, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Copenhagen O, 2100, Denmark.
Gjertrud L LaurellNeurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Rigshospitalet, Building 8057, Blegdamsvej 9, Copenhagen, 8057, DK-2100, Denmark.
Susan HerrmannDepartment of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark.
Arafat NasserNeurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Rigshospitalet, Building 8057, Blegdamsvej 9, Copenhagen, 8057, DK-2100, Denmark.
Annette JohansenNeurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Rigshospitalet, Building 8057, Blegdamsvej 9, Copenhagen, 8057, DK-2100, Denmark.
Anton LundDepartment of Neuroanaesthesiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, 2100, Denmark.
Thomas L AndersenDepartment of Clinical Physiology & Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, 2100, Denmark.
Gitte M Knudsen *Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Rigshospitalet, Building 8057, Blegdamsvej 9, Copenhagen, 8057, DK-2100, Denmark.
Lars H Pinborg *Epilepsy Clinic, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, Copenhagen O, 2100, Denmark. lars.pinborg@nru.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHere, we evaluate a PET displacement model with a Single-step and Numerical solution in healthy individuals using the synaptic vesicle glycoprotein (SV2A) PET-tracer [

methodsEleven healthy individuals (five females, mean age 35.5 [range: 25-47] years) underwent two 120-min [

resultsSV2A occupancies and V

conclusionPlasma LEV concentration vs. SV2A occupancy can be determined in humans using a single PET scan displacement model. The average concentration of the three computed IC CLINICAL

trial registrationNCT05450822. Retrospectively registered 5 July 2022 https://clinicaltrials.gov/ct2/results? term=NCT05450822&Search=Search.

Indexed as

BrainLevetiracetamPositron-Emission TomographyAdultFemaleHumansMaleMembrane GlycoproteinsMiddle AgedNerve Tissue ProteinsProspective StudiesPyridinesPyrrolidinonesRadiopharmaceuticals1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-oneLevetiracetamMembrane GlycoproteinsNerve Tissue ProteinsPyridinesPyrrolidinonesRadiopharmaceuticalsSV2A protein, humanDisplacementHalf maximal inhibitory concentrationHealthy volunteersLevetiracetamOccupancyPET kinetic modeling

Identifiers

PMID38758370
PMCPMC11369007

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.