Evidence map›Paper›PMID 38758353›Full record

SynthesisActa neurologica Belgica2024

Patients' and caregivers' attitudes towards patient assisted suicide or euthanasia in amyotrophic lateral sclerosis-a meta-analysis.

Ioannis Mavroudis, Pavlina Alexiou, Foivos Petridis, Alin Ciobica, Ioana Miruna Balmus, Bogdan Gireadă, Irina Luciana Gurzu, Otilia Novac, Bogdan Novac

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Acta neurologica Belgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neurology and physician-assisted suicide: glossary of definitions and terminology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ioannis MavroudisDepartment of Neuroscience, Leeds Teaching Hospitals, Leeds, UK.
Pavlina AlexiouSchool of Theology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Foivos PetridisThird Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Alin CiobicaDepartment of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Carol I Avenue, No. 20A, 700506, Iasi, Romania. alin.ciobica@uaic.ro.ORCID http://orcid.org/0000-0002-1750-6011
Ioana Miruna BalmusDepartment of Exact Sciences and Natural Sciences, Institute of Interdisciplinary Research, Alexandru Ioan Cuza University of Iasi, Alexandru Lapusneanu Street, No. 26, 700057, Iasi, Romania.
Bogdan GireadăDepartment of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universitătii Street, 700115, Iasi, Romania.
Irina Luciana GurzuFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 16 Universitătii Street, 700115, Iasi, Romania. irinaluciana.gurzu@umfiasi.ro.
Otilia NovacFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 16 Universitătii Street, 700115, Iasi, Romania.
Bogdan NovacFaculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 16 Universitătii Street, 700115, Iasi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assisted suicide and euthanasia are long debated topics in amyotrophic lateral sclerosis (ALS) patients care. We conducted a meta-analysis to evaluate the attitudes of ALS patients and their caregivers toward physician-assisted suicide (PAS) and euthanasia. Also, we were interested to identify the factors associated with the positive or negative attitude of patients and caregivers towards PAS/euthanasia. A thorough search of the online databases (PubMed, Cochrane Library, and Web of Science) was conducted and eligibility criteria according to the PRISMA guidelines were used to include the studies in the current meta-analysis. The assessment of the quality of the selected studies was carried out using a pre-specified set of criteria by Cochrane. The studies that were selected for this meta-analysis suggested that the expression of the wish to die is more likely correlated with depression, anxiety, hopelessness, and lack of optimism. The overall prevalence of considering PAS/euthanasia significantly varies in a dependent manner over the cultural, legal, and societal factors. In this context, we found that the opinion on this topic can be deeply personal and may vary widely among individuals and communities. Lower quality of life and lower religiosity were associated with a positive attitude toward PAS/euthanasia. On the other hand, patients who are more religious are less likely to choose PAS/euthanasia. Gender does not appear to play a significant role in determining attitudes towards PAS/euthanasia in ALS patients. Other factors, such as education and psychological state, could also be important. In conclusion, end-of-life decisions in ALS patients are complex and require careful consideration of individual values, beliefs, and preferences. Understanding the factors that influence a patient's attitude towards PAS/euthanasia can help healthcare providers to offer appropriate care and support for these patients and their families.

Indexed as

Amyotrophic Lateral SclerosisCaregiversEuthanasiaSuicide, AssistedAttitude to DeathHumansAmyotrophic lateral sclerosisAssisted suicideCaregiversEuthanasiaPatients

Identifiers

PMID38758353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.