Evidence map›Paper›PMID 38758282›Full record

ArticleJournal of neurology2024

Profiles of motivational impairment and their relationship to functional decline in frontotemporal dementia.

Siobhán R Shaw, Kristina S Horne, Olivier Piguet, Rebekah M Ahmed, Alexis E Whitton, Muireann Irish

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siobhán R ShawBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Kristina S HorneBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Olivier PiguetBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Rebekah M AhmedBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Alexis E WhittonBlack Dog Institute, University of New South Wales, Sydney, NSW, Australia.
Muireann IrishBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia. muireann.irish@sydney.edu.au.ORCID http://orcid.org/0000-0002-4950-8169

Funding

Australian Research Council CE11000102Department of Health and Aged Care, Australian Government GNT2024329National Health and Medical Research Council GNT1037746National Health and Medical Research Council GNT2017521National Health and Medical Research Council GNT2025228National Institute for Dementia Research GNT2008020
6 · The paper itself

Abstract

Motivational disturbances are pervasive in frontotemporal dementia (FTD) and impact negatively on everyday functioning. Despite mounting evidence of anhedonia in FTD, it remains unclear how such changes fit within the broader motivational symptom profile of FTD, or how anhedonia relates to functional outcomes. Here we sought to comprehensively characterize motivational disturbances in FTD and their respective relationships with functional impairment. A cross-sectional study design was used including 211 participants-68 behavioral-variant FTD (bvFTD), 32 semantic dementia (SD), 43 Alzheimer's disease (AD), and 68 healthy older control participants. Anhedonia severity was measured using the Snaith-Hamilton Pleasure Scale while severity of apathy was assessed across Emotional, Executive, and Initiation dimensions using the Dimensional Apathy Scale. Functional impairment was established using the FTD Functional Rating Scale (FRS). Distinct motivational profiles emerged in each dementia syndrome: a domain-general motivational impairment in bvFTD; a predominantly anhedonic profile in SD; and more pronounced initiation and executive apathy in AD. Correlation analyses revealed differential associations between motivational symptoms and severity of functional impairment in each group. Executive apathy was associated with functional impairment in bvFTD, while anhedonia was strongly correlated with functional decline in SD. Finally, executive and emotional apathy were associated with functional decline in AD. Our study indicates distinct profiles of apathy and anhedonia in FTD syndromes, which in turn are differentially associated with functional decline. This detailed characterization of motivational phenotypes can inform patient stratification for targeted interventions to improve functional outcomes.

Indexed as

AnhedoniaApathyFrontotemporal DementiaMotivationAgedAlzheimer DiseaseCross-Sectional StudiesExecutive FunctionFemaleHumansMaleMiddle AgedAnhedoniaApathyFunctional impairmentMotivationNeuropsychiatryYounger-onset dementia

Identifiers

PMID38758282
PMCPMC11319612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.