Evidence map›Paper›PMID 38758207›Full record

ArticleThe Pediatric infectious disease journal2024

Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia.

Michael J Carter, Sonu Shrestha, Peter O'Reilly, Pallavi Gurung, Meeru Gurung, Stephen Thorson, Rama Kandasamy, Merryn Voysey, Elizabeth O'Mahony, Sarah Kelly and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pediatric infectious disease journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Michael J CarterPaediatric Intensive Care, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.ORCID 0000-0003-3403-4746
Sonu ShresthaOxford Vaccine Group, Department of Paediatrics, University of Oxford.
Peter O'ReillyOxford Vaccine Group, Department of Paediatrics, University of Oxford.
Pallavi GurungPediatric Research Group, Patan Academy of Health Sciences, Patan, Kathmandu, Nepal.
Meeru GurungPediatric Research Group, Patan Academy of Health Sciences, Patan, Kathmandu, Nepal.
Stephen ThorsonPediatric Research Group, Patan Academy of Health Sciences, Patan, Kathmandu, Nepal.
Rama KandasamyDiscipline of Paediatrics and Child Health, School of Clinical Medicine, University of New South Wales.ORCID 0000-0002-3111-5586
Merryn VoyseyOxford Vaccine Group, Department of Paediatrics, University of Oxford.ORCID 0000-0001-6324-6559
Elizabeth O'MahonyOxford Vaccine Group, Department of Paediatrics, University of Oxford.
Sarah KellyOxford Vaccine Group, Department of Paediatrics, University of Oxford.
Imran AnsariPediatric Research Group, Patan Academy of Health Sciences, Patan, Kathmandu, Nepal.
Ganesh ShahPediatric Research Group, Patan Academy of Health Sciences, Patan, Kathmandu, Nepal.
Puja AmatyaPediatric Research Group, Patan Academy of Health Sciences, Patan, Kathmandu, Nepal.
Irina TcherniaevaCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Guy BerbersCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
David R MurdochDepartment of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand.ORCID 0000-0003-0070-8001
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford.ORCID 0000-0001-7361-719
Shrijana ShresthaPediatric Research Group, Patan Academy of Health Sciences, Patan, Kathmandu, Nepal.ORCID 0000-0001-9484-0227
Dominic F KellyOxford Vaccine Group, Department of Paediatrics, University of Oxford.ORCID 0000-0002-6063-8896
on behalf the PneumoNepal Study Group

Funding

Wellcome Trust 104439
6 · The paper itself

Abstract

We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for pneumococcal infection in children with pneumonia in Nepal. Children with pneumococcal pneumonia did not have higher convalescent, or higher fold change, IgG to pneumococcal polysaccharides than children with other causes of pneumonia. Caution is needed in interpreting antibody responses in pneumococcal infections.

Indexed as

Antibodies, BacterialCommunity-Acquired InfectionsImmunoglobulin GPneumonia, PneumococcalPolysaccharides, BacterialStreptococcus pneumoniaeBacterial CapsulesChildChild, PreschoolFemaleHumansInfantMaleNepalAntibodies, BacterialImmunoglobulin GPolysaccharides, Bacterial

Identifiers

PMID38758207
PMCPMC10789377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.