ArticleAmerican journal of physiology. Heart and circulatory physiology2024
Fetal cardiac troponin I levels decline toward birth in sheep.
Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Development of striated muscle microvasculature across the perinatal period in lambs.The Journal of physiology · 2026Article
- Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs.BMC veterinary research · 2026Article
- Subcutaneous Buprenorphine Is an Acceptable Preoperative Analgesic in Pregnant Ewes Undergoing Hysterotomy (Ovis aries).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Enhanced myocardial perfusion in late gestation fetal lambs with impaired left ventricular inflow.The Journal of physiology · 2025Article
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Authors and funding
2 authors.
Funding
Abstract
Elevated cardiac troponin I (cTnI), a myocardial damage biomarker, has been reported in cord blood of neonates delivered vaginally or by cesarean section. Although the neonatal peak likely reflects the physiological adjustment to extrauterine life, a better understanding of serial prepartum changes is required to determine physiological causes of fetal cTnI release. We longitudinally sampled eight healthy lambs (20 days before spontaneous birth to 5 days postnatal), and from three fetuses receiving intravenous IGF-1. Samples were collected into heparin, and the plasma was stored at -80°C for later determination of high-sensitivity (hs) cTnI levels (BeckmanCoulter UniCel DxI Access IA; log transformed detection limit = 0.30, quantification limit = 0.78, 99th percentile = 1.78). Positive and negative control samples were drawn from an adult ewe during a terminal experiment (myocardial ischemia) and similarly assessed. hs-cTnI data were log transformed from ng/L. Log(hs-cTnI) was 1.47 ± 0.30 (means ± SD) at 20 days before birth and declined to 1.02 ± 0.65 in fetuses 12 ± 4 h before birth (
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