Evidence map›Paper›PMID 38757734›Full record

ArticleThe Kaohsiung journal of medical sciences2024

Mechanical shear flow regulates the malignancy of colorectal cancer cells.

Yu-Ting Tseng, Ching-Chung Tsai, Ping-Chen Chen, Bo-Yan Lin, Sodio C N Hsu, Shu-Ping Huang, Bin Huang

Abstract read
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu-Ting TsengDepartment of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ching-Chung TsaiSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Ping-Chen ChenDepartment of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
Bo-Yan LinDepartment of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
Sodio C N HsuDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-2576-7289
Shu-Ping HuangDepartment of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
Bin HuangDepartment of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-1268-402X

Funding

Kaohsiung Medical University 101CM-KMU-01Kaohsiung Medical University KMU-TC108A02Kaohsiung Medical University KMU-TC111A02-0Kaohsiung Medical University NSYSUKMU105-P032Kaohsiung Medical University NSYSUKMU106-P009Ministry of Science and Technology MOST 109-2314-B-037-118Ministry of Science and Technology MOST 110-2314-B-037-140Ministry of Science and Technology MOST 111-2314-B-037-008
6 · The paper itself

Abstract

Colorectal cancer (CRC) is notable for its high mortality and high metastatic characteristics. The shear force generated by bloodstream provides mechanical signals regulating multiple responses of cells, including metastatic cancer cells, dispersing in blood vessels. We, therefore, studied the effect of shear flow on circulating CRC cells in the present study. The CRC cell line SW620 was subjected to shear flow of 12.5 dynes/cm

Indexed as

ApoptosisCell MovementColorectal NeoplasmsEpithelial-Mesenchymal TransitionReactive Oxygen SpeciesCadherinsCaspase 3Caspase 9Cell Line, TumorCyclin D1HumansMembrane Potential, MitochondrialNitric OxideOxidative StressStress, MechanicalTwist-Related Protein 1CadherinsCaspase 3Caspase 9Cyclin D1Nitric OxideReactive Oxygen SpeciesTwist-Related Protein 1Zonula Occludens-1 Proteinapoptosiscolorectal cancerEMTmitochondriashear flow

Identifiers

PMID38757734
PMCPMC11895591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.