Evidence map›Paper›PMID 38757665›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.

Xiaoyan Meng, Zhonglong Liu, Liang Deng, Yangzi Yang, Yingchun Zhu, Xiaoying Sun, Yongqiang Hao, Yue He, Jingke Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Dual metabolic checkpoint blockadeBioactive materials · 2027
    Article
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  5. Research progress in clinical utilization of HFrontiers in pharmacology · 2026
    Review
  6. Research Progress of Molecular HDrug design, development and therapy · 2026
    Review
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  8. Review
  9. Review
  10. Article
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  14. Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoyan MengDepartment of Oral Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
Zhonglong LiuDepartment of Oral Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
Liang DengShanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
Yangzi YangDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Navy Medical University, No. 415 Fengyang Road, Shanghai, 200003, P. R. China.
Yingchun ZhuKey Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.
Xiaoying SunCollege of Sciences, Shanghai University, Shanghai, 200444, P. R. China.
Yongqiang HaoShanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
Yue HeDepartment of Oral Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
Jingke FuShanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.ORCID 0000-0003-0554-9046

Funding

Biobank project by Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine YBKB202105Biomaterials and Regenerative Medicine Institute Cooperative Research Project, Shanghai Jiao Tong University School of Medicine 2022LHA01National Key Research & Development Program of China 2022YFC2406000National Natural Science Foundation of China 82173451National Natural Science Foundation of China 82273489Shanghai Municipal Health Commission 2022LJ001
6 · The paper itself

Abstract

Tumor microenvironment (TME) plays an important role in the tumor progression. Among TME components, cancer-associated fibroblasts (CAFs) show multiple tumor-promoting effects and can induce tumor immune evasion and drug-resistance. Regulating CAFs can be a potential strategy to augment systemic anti-tumor immunity. Here, the study observes that hydrogen treatment can alleviate intracellular reactive oxygen species of CAFs and reshape CAFs' tumor-promoting and immune-suppressive phenotypes. Accordingly, a controllable and TME-responsive hydrogen therapy based on a CaCO

Indexed as

Cancer-Associated FibroblastsHydrogenPhenotypeTumor MicroenvironmentAnimalsCalcium CarbonateCell Line, TumorDisease Models, AnimalFemaleHumansMiceMice, Inbred BALB CNanoparticlesCalcium CarbonateHydrogencancer‐associated fibroblastshydrogen therapyimmunotherapytumor microenvironment

Identifiers

PMID38757665
PMCPMC11267370

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.