Evidence map›Paper›PMID 38757318›Full record

ArticleMedicinal chemistry (Shariqah (United Arab Emirates))2024

Karina Vázquez, Adriana Moreno-Rodríguez, Luis R Domínguez-Díaz, Jeanluc Bertrand, Cristian O Salas, Gildardo Rivera, Yobana Pérez Cervera, Virgilio Bocanegra-García

Abstract read
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In one paragraph

Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trypanocidal Activity of Dual Redox-Active Quinones:Pathogens (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karina VázquezFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Nuevo León, General Escobedo, Nuevo León, C.P. 66050, México.ORCID 0000-0002-5081-0904
Adriana Moreno-RodríguezFacultad de Ciencias Químicas, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca 68120, México.ORCID 0000-0003-4100-8255
Luis R Domínguez-DíazFacultad de Ciencias Químicas, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca 68120, México.ORCID 0000-0003-1935-3239
Jeanluc BertrandFacultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago de Chile, Chile.ORCID 0000-0002-6247-0652
Cristian O SalasFacultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843 Santiago de Chile, Chile.ORCID 0000-0001-7620-2459
Gildardo RiveraCentro de Biotecnología Genómica, Instituto Politécnico Nacional, 88710 Reynosa, Tamaulipas, México.ORCID 0000-0001-9842-4167
Yobana Pérez CerveraFacultad de Odontología, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca 68120, México.ORCID 0000-0001-9932-247X
Virgilio Bocanegra-GarcíaCentro de Biotecnología Genómica, Instituto Politécnico Nacional, 88710 Reynosa, Tamaulipas, México.ORCID 0000-0002-0728-2018

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChagas disease, a condition caused by Trypanosoma cruzi, is an endemic disease in Latin American countries that affects approximately eight million people worldwide. It is a continuing public health problem. As nifurtimox and benznidazole are the two pharmacological treatments currently used to treat it, the present research proposes new therapeutic alternatives. Previous studies conducted on naphthoquinone derivatives have found interesting trypanocidal effects on epimastigotes, with the molecules 2-phenoxy-1,4-naphthoquinone (IC

methodsThe present study evaluated the efficacy of

resultsThe

conclusionThese are encouraging results for proposing new naphthoquinone derivatives with potential anti-

Indexed as

Chagas DiseaseNaphthoquinonesTrypanocidal AgentsTrypanosoma cruziAnimalsMiceMolecular StructureStructure-Activity RelationshipNaphthoquinonesTrypanocidal Agentsaryloxy-naphthoquinonesin vivo assaymouse modelnaphthoquinone derivatives.Trypanosoma cruzitrypanosomicidal activity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.