Evidence map›Paper›PMID 38757269›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Sex-Dependency of T Cell-Induced Salt-Sensitive Hypertension and Kidney Damage.

Justine M Abais-Battad, John Henry Dasinger, Hayley Lund, Emily C Burns-Ray, Samuel D Walton, Kaitlyn E Baldwin, Daniel J Fehrenbach, Mary Cherian-Shaw, David L Mattson

Abstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Salt and chronic kidney disease.Nature reviews. Nephrology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. HMGB1 drives T-cell activation in hypertensive males and females.American journal of physiology. Renal physiology · 2025
    Article
  15. Recent advances on immunity and hypertension: the new cells on the kidney block.American journal of physiology. Renal physiology · 2025
    Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Justine M Abais-Battad *Department of Physiology, Medical College of Georgia, Augusta University (J.M.A.-B., J.H.D., E.C.B.-R., S.D.W., K.E.B., M.C.-S., D.L.M.).
John Henry Dasinger *Department of Physiology, Medical College of Georgia, Augusta University (J.M.A.-B., J.H.D., E.C.B.-R., S.D.W., K.E.B., M.C.-S., D.L.M.).ORCID 0000-0001-6667-0427
Hayley LundDepartment of Medicine, Medical College of Wisconsin, Milwaukee (H.L.).
Emily C Burns-RayDepartment of Physiology, Medical College of Georgia, Augusta University (J.M.A.-B., J.H.D., E.C.B.-R., S.D.W., K.E.B., M.C.-S., D.L.M.).
Samuel D WaltonDepartment of Physiology, Medical College of Georgia, Augusta University (J.M.A.-B., J.H.D., E.C.B.-R., S.D.W., K.E.B., M.C.-S., D.L.M.).ORCID 0000-0002-8460-2214
Kaitlyn E BaldwinDepartment of Physiology, Medical College of Georgia, Augusta University (J.M.A.-B., J.H.D., E.C.B.-R., S.D.W., K.E.B., M.C.-S., D.L.M.).
Daniel J FehrenbachDepartment of Medicine, Indiana University School of Medicine, Indianapolis (D.J.F.).ORCID 0000-0003-3382-464X
Mary Cherian-ShawDepartment of Physiology, Medical College of Georgia, Augusta University (J.M.A.-B., J.H.D., E.C.B.-R., S.D.W., K.E.B., M.C.-S., D.L.M.).ORCID 0000-0002-8079-6453
David L MattsonDepartment of Physiology, Medical College of Georgia, Augusta University (J.M.A.-B., J.H.D., E.C.B.-R., S.D.W., K.E.B., M.C.-S., D.L.M.).ORCID 0000-0002-5401-0269

Funding

Immunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0M
Gut Metabolites, T cells, and Salt-Sensitive HypertensionR01HL166458 · NHLBI · AUGUSTA UNIVERSITY · PI David L. Mattson, Aaron James Polichnowski · 2023 to 2026
$2.4M
CD14 and Salt-Sensitive HypertensionR01HL161231 · NHLBI · AUGUSTA UNIVERSITY · PI MATTSON, DAVID L. · 2022 to 2025
$2.0M
Nox2-derived oxidative stress produced by T cells contributes to the development of maternal syndrome in the Dahl salt-sensitive rat.R00HL157549 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI John H Dasinger · 2024 to 2026
$747k
Nox2-derived oxidative stress produced by T cells contributes to the development of maternal syndrome in the Dahl salt-sensitive rat.K99HL157549 · NHLBI · AUGUSTA UNIVERSITY · PI DASINGER, JOHN H · 2022 to 2023
$205k
NHLBI NIH HHS K99 HL157549NHLBI NIH HHS R00 HL157549NHLBI NIH HHS R01 HL161231NHLBI NIH HHS R01 HL166458NIAID NIH HHS T32 AI060519
6 · The paper itself

Abstract

backgroundIt is established that the immune system, namely T cells, plays a role in the development of hypertension and renal damage in male Dahl salt-sensitive (SS) rats, but far less is known about this relationship in females. Rats with genetically deleted T cells via

methodsWe assessed the hypertensive and kidney injury phenotypes in male versus female SS and SS

resultsThe lack of functional T cells in SS

conclusionsThe absence of T cells in the SS

Indexed as

HypertensionRats, Inbred DahlT-LymphocytesAdoptive TransferAnimalsBlood PressureDisease Models, AnimalFemaleKidneyMaleRatsSex FactorsSodium Chloride, DietarySodium Chloride, Dietaryhypertensionimmune systemkidney diseasessex characteristicssodium chloride, dietaryT-lymphocytes

Identifiers

PMID38757269
PMCPMC11168867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.