Evidence map›Paper›PMID 38757260›Full record

ArticleAnnals of geriatric medicine and research2024

Psychomotor Symptoms, Cognitive Impairments, and Suicidal Thoughts after COVID-19 Infection: A Case Report and Possible Allostatic Mechanism.

Ying Lin, Chen Lin, Jason Hong-Yi Chang, Dai-Lun Chiang, Feipei Lai, Chen-Ju Lin

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of geriatric medicine and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying LinDepartment of Psychiatry, MacKay Memorial Hospital, Taipei, Taiwan.
Chen LinDepartment of Biomedical Sciences and Engineering, National Central University, Chunli, Taiwan.
Jason Hong-Yi ChangDepartment of Psychiatry, MacKay Memorial Hospital, Taipei, Taiwan.
Dai-Lun ChiangFinancial Technology Applications Program, Ming Chuan University, Taoyuan, Taiwan.
Feipei LaiGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
Chen-Ju LinDepartment of Psychiatry, MacKay Memorial Hospital, Taipei, Taiwan.

Funding

National Science and Technology Council, Taiwan 111-2635-E-130-002
6 · The paper itself

Abstract

Although neuropsychiatric manifestations are common in survivors of coronavirus disease 2019 (COVID-19), the pathophysiology is not yet elucidated. Here we describe the case of a geriatric inpatient who developed post-COVID depression with psychomotor retardation, anxiety, hopelessness, executive function problems, and suicidal ideations. The language problems and cognitive impairments coemerged with the motor problems. We propose a mechanism associated with problems in energy prediction and regulation in which the coronavirus infection, which causes neuroinflammation and viral activity in the nervous system, interferes with the reward pathway and sensory prediction process. Sigma-1 receptor agonists such as sertraline may regulate energy expenditure and, thus, be beneficial to the process. The treatment improvements in our patient included those in the autonomic nervous system, activity, and circadian rhythm.

Indexed as

Cognitive DysfunctionCOVID-19SARS-CoV-2Suicidal IdeationAgedAllostasisDepressionHumansMaleAgedAllostasisCOVID-19COVID brain fogPost-acute COVID-19 syndrome

Identifiers

PMID38757260
PMCPMC11467520

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.