Evidence map›Paper›PMID 38757191›Full record

ArticleObstetrics & gynecology science2024

Evaluation of oxidative stress and inflammation in patients with polycystic ovary syndrome.

Berra Sen, Senem Gonultas, Ceren Albayrak, Sevval Temur, Ilgar Acar, Beyza Nur Ozkan, Havva Sevde Islek, Muserref Banu Yilmaz, Ebru Kale, Eray Metin Guler

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Article in Obstetrics & gynecology science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Berra SenDepartment of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul, Turkey.
Senem GonultasDepartment of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul, Turkey.
Ceren AlbayrakDepartment of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul, Turkey.
Sevval TemurDepartment of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul, Turkey.
Ilgar AcarDepartment of Medical School Education, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul, Turkey.
Beyza Nur OzkanDepartment of Medical Biochemistry, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul, Turkey.
Havva Sevde IslekDepartment of Obstetrics and Gynecology, Bezmialem Vakif University, Istanbul, Turkey.
Muserref Banu YilmazDepartment of Obstetrics and Gynecology, University of Health Sciences Turkey, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Istanbul, Turkey.
Ebru KaleDepartment of Medical Biochemistry, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul, Turkey.
Eray Metin GulerDepartment of Medical Biochemistry, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePolycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder characterized by hyperandrogenism, hyperinsulinemia, and insulin resistance. The prevalence of PCOS is increasing worldwide. Although the etiology of this disease is currently unknown, it is thought to be closely related to inflammation and oxidative stress. Our study aimed to compare patients have PCOS to healthy volunteers and assess the changes in oxidative stress and inflammatory parameters in these patients.

methodsThirty patients between the ages of 18-45 diagnosed with PCOS and 30 healthy volunteers with the same demographic characteristics were included in this study. Clinical parameters were measured using immunoassays. Oxidative stress biomarkers, total oxidant (TOS), total antioxidant (TAS), total thiol (TT), and native thiol (NT) levels were measured using photometric methods according to Erel's method. The dynamic disulfide level (DIS) and oxidative stress index (OSI) were calculated using mathematical equations. Among the inflammatory parameters, values for interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were measured photometrically using commercially purchased kits.

resultsMoreover, TT and NT levels were lower in patients with PCOS compared to those in the healthy group statistically significantly (P<0.001). In addition, TAS, TOS, OSI, DIS, IL-1β, IL-6, and TNF-α levels were identified to be significantly higher in the patients with PCOS than those in the healthy group (P<0.001).

conclusionEvaluation of oxidative stress and clinical parameters used in the follow-up may be beneficial for the disease.

Indexed as

DisulfideInflammationOxidative stressPolycystic ovary syndromeReactive oxygen species

Identifiers

PMID38757191
PMCPMC11266846

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