Evidence map›Paper›PMID 38757028›Full record

ArticleArchives of medical science : AMS2024

Comparing prophylactic effect of exercise and metformin on cognitive brain functions in rats with type 3 diabetes mellitus.

Hader Ibrahim Sakr, Mohamed A Amen, Laila A Rashed, Akef A Khowailed, Hazem A Sayed, Moustafa E Motawee, Hany Sakr, Mohamed Mansour Khalifa

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In one paragraph

Article in Archives of medical science : AMS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hader Ibrahim SakrDepartment of Medical Physiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed A AmenDepartment of Medical Physiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Laila A RashedDepartment of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
Akef A KhowailedDepartment of Medical Physiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Hazem A SayedDepartment of Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Moustafa E MotaweeDepartment of Histology and Cytology, Faculty of Medicine, Alazhar University, Cairo, Egypt.
Hany SakrDepartment of Pathology and Laboratory Medicine, VAMC North East Ohio Healthcare System, Louis Stokes, Cleveland, Ohio, USA.
Mohamed Mansour KhalifaDepartment of Medical Physiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) are two major medical conditions that constitute a significant financial burden on most healthcare systems. Due to AD sharing "insulin resistance" mechanistic features with DM, some scientists have proposed "type 3 DM" terminology for it. This study aims to compare the prophylactic effect of exercise and metformin on cognitive brain functions in rats with type 3 DM. Material and methods: Two groups of rats were included in the study: the control group ( Results: Serum glucose, FFA, TG, cholesterol, LDL, brain Aβ-42, brain glucose, the number of hippocampal dark and degenerated cells, and brain Aβ-42 and tau-positive cells, were all significantly lower. In contrast, serum insulin and HDL, the number of hippocampal granular cells, and latency of the step-down avoidance task were significantly higher in exercised and metformin-treated groups compared to the diabetic group. There were significantly higher values of serum insulin and brain/plasma glucose ratio and number of brain tau-positive cells in the metformin-treated group than in the exercised group. Conclusions: We can conclude that exercise can be as effective as metformin regarding prophylaxis against the deleterious effects of type 3 DM on cognitive brain functions.

Indexed as

Alzheimer’s diseasediabetes mellitushippocampusmetformintreadmill exercise

Identifiers

PMID38757028
PMCPMC11094824

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.