Evidence map›Paper›PMID 38756798›Full record

ArticleChemical science2024

Molecular mechanism of α-synuclein aggregation on lipid membranes revealed.

Alexander J Dear, Xiangyu Teng, Sarah R Ball, Joshua Lewin, Robert I Horne, Daniel Clow, Alisdair Stevenson, Natasha Harper, Kim Yahya, Xiaoting Yang and 7 more

Abstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
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  10. Global kinetic model of lipid-inducedProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Detection of protein oligomers with nanopores.Nature reviews. Chemistry · 2025
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alexander J DearWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Xiangyu TengWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Sarah R BallWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Joshua LewinWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Robert I HorneWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Daniel ClowWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Alisdair StevensonDepartment of Biology, Institute of Biochemistry, ETH Zurich Otto Stern Weg 3 8093 Zurich Switzerland.
Natasha HarperWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Kim YahyaWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Xiaoting YangWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.ORCID https://orcid.org/0000-0002-5909-2232
Suzanne C BrewertonWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
John ThomsonWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Thomas C T MichaelsDepartment of Biology, Institute of Biochemistry, ETH Zurich Otto Stern Weg 3 8093 Zurich Switzerland.
Sara LinseWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Tuomas P J KnowlesYusuf Hamied Department of Chemistry, University of Cambridge Cambridge UK.
Johnny HabchiWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.
Georg MeislWaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.ORCID https://orcid.org/0000-0002-6562-7715

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α-synuclein is relatively stable

Identifiers

PMID38756798
PMCPMC11095391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.