ArticlePain reports2024
Evaluation of the effect of intraoperative tropisetron on postoperative rebound pain after brachial plexus block: a randomized controlled trial.
Article in Pain reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Rebound pain following peripheral nerve block in extremity fracture surgery: pathophysiological mechanisms based on the "Triple-Hit" model and multimodal preventive strategies.Frontiers in medicine · 2026Review
- Clinical practice guidelines for postoperative pain management in adults (2024 edition).Journal of anesthesia and translational medicine · 2025Review
- Development and validation of a nomogram for predicting postoperative new-onset constipation in elderly patients undergoing hip fracture surgery.Scientific reports · 2025Article
- A machine learning-based framework for predicting postpartum chronic pain: a retrospective study.BMC medical informatics and decision making · 2025Article
- Prevalence and Predictors of Severity of Rebound Pain After Regional Anesthesia in Patients Undergoing Orthopedic Surgery: A Cross-Sectional Study.Pain research & management · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Postoperative rebound pain after peripheral nerve block increases patient suffering and delays recovery after surgery. Objectives: We tested whether the 5HT-3 receptor antagonist and α7nAChR agonist tropisetron could prevent postoperative rebound pain. Methods: A total of 115 patients were randomized to receive 5-mg/5-mL tropisetron or the same volume of normal saline. Pain intensity was measured with the numerical rating scale of pain (NRS). Rebound pain was defined as a change from mild pain (NRS ≤ 3) measured in the postanesthesia care unit to severe pain (NRS ≥ 7) within 24 hours after peripheral nerve blockade. Logistic regression was used to identify relevant factors associated with postoperative rebound pain. Results: Tropisetron did not affect the NRS score or the incidence of rebound pain after peripheral nerve block. Logistic regression revealed that preoperative pain, bone surgery, and length of incision were risk factors for postoperative rebound pain, and patient-controlled analgesia was protective against postoperative rebound pain. Conclusion: Tropisetron does not affect the incidence of rebound pain after peripheral nerve block. Patients at high risk of postoperative rebound pain should be identified for appropriate management. Registration site: www.chictr.org.cn (ChiCTR2300069994).
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