Mitochondrial DNA Missense Mutations ChrMT: 8981A > G and ChrMT: 6268C > T Identified in a Caucasian Female with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Triggered by the Epstein-Barr Virus.

Gaoyan G Tang-Siegel, David W Maughan, Milah B Frownfelter, Alan R Light

Abstract readCase Reports

In one paragraph

Article in Case reports in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Gaoyan G Tang-SiegelDepartment of Molecular Physiology and Biophysics, College of Medicine, University of Vermont, Burlington, VT, USA.ORCID https://orcid.org/0000-0002-2245-0227

David W MaughanDepartment of Molecular Physiology and Biophysics, College of Medicine, University of Vermont, Burlington, VT, USA.

Milah B FrownfelterSeattle Medical Associates, 1124 Columbia St. Suite 620, Seattle, WA, USA.

Alan R LightDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Frances E. Carr · 2017 to 2026

$51.6M

NIGMS NIH HHS U54 GM115516

6 · The paper itself

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem disabling disease with unclear etiology and pathophysiology, whose typical symptoms include prolonged debilitating recovery from fatigue or postexertional malaise (PEM). Disrupted production of adenosine triphosphate (ATP), the intracellular energy that fuels cellular activity, is a cause for fatigue. Here, we present a long-term case of ME/CFS: a 75-year-old Caucasian female patient, whose symptoms of ME/CFS were clearly triggered by an acute infection of the Epstein-Barr virus 24 years ago (mononucleosis). Before then, the patient was a healthy professional woman. A recent DNA sequence analysis identified missense variants of mitochondrial respiratory chain enzymes, including

Identifiers

PMID38756740

DOI10.1155/2024/6475425

PMCPMC11098598

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