Evidence map›Paper›PMID 38756375›Full record

ArticleFrontiers in pharmacology2024

Exosomes derived from HUVECs alleviate ischemia-reperfusion induced inflammation in neural cells by upregulating KLF14 expression.

Jianxin Qin, Lihong Zhou, Lei Yu, Jingwen Ye, Feng Wang, Jin Zhou, Yunjuan Gu, Gang Chen, Xia Chen

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jianxin Qin *Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
Lihong Zhou *Department of Histology and Embryology, Medical School of Nantong University, Nantong, China.
Lei Yu *Department of Endocrinology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Jingwen YeDepartment of Histology and Embryology, Medical School of Nantong University, Nantong, China.
Feng WangNantong Xingzhong Cell Engineering Co. Ltd, Nantong, China.
Jin ZhouNantong Xingzhong Cell Engineering Co. Ltd, Nantong, China.
Yunjuan GuDepartment of Endocrinology, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.
Gang ChenDepartment of Histology and Embryology, Medical School of Nantong University, Nantong, China.
Xia ChenDepartment of Histology and Embryology, Medical School of Nantong University, Nantong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation plays a key role in the progression of secondary brain injury after ischemic stroke, and exosomes have been increasingly recognized to eliminate inflammatory responses through various mechanisms. This study aimed to explore the effect and possible mechanism of human umbilical vein endothelial cells derived exosomes (H-EXOs) on neuroinflammation. We established a transient middle cerebral artery occlusion/reperfusion (tMCAO/R) in male rats and oxygen-glucose-deprivation/reoxygenation (OGD/R) model in cultured neurons to mimic secondary brain injury after ischemic stroke

Indexed as

brain ischemicexosomesHUVECinflammationKLF14

Identifiers

PMID38756375
PMCPMC11096520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.