Evidence map›Paper›PMID 38756341›Full record

ArticleNeuro-ophthalmology (Aeolus Press)2024

Peripheral Retinal Haemorrhages in a Patient with MOG-Associated Optic Neuritis.

Georgia A Wilke, Madeline Spencer, Carley A Gilman, Rejean Guerriero, Parker Bohm, Gregory P Van Stavern, Andrew R Lee

Abstract readCase Reports
In one paragraph

Article in Neuro-ophthalmology (Aeolus Press), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Georgia A WilkeDepartment of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, Missouri, USA.
Madeline SpencerDepartment of Paediatrics, Washington University in St. Louis, St. Louis, Missouri, USA.
Carley A GilmanDivision of Paediatric Neurology, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Rejean GuerrieroDivision of Paediatric Neurology, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Parker BohmNeurology Consultants of Kansas, Wichita, Kansas, USA.
Gregory P Van StavernDepartment of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, Missouri, USA.
Andrew R LeeDepartment of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, Missouri, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 15-year-old female presented with headaches and bilateral vision loss. Fundoscopic examination revealed bilateral optic nerve oedema as well as peripheral retinal haemorrhages. Magnetic resonance imaging of the brain showed findings consistent with bilateral optic neuritis. The patient was started on high dose intravenous corticosteroids but her vision failed to improve. The presence of retinal haemorrhages raised concern that a vasculitis was underlying her symptoms, prompting an extensive work-up, which was unrevealing. Plasmapheresis was initiated and the patient's vision eventually improved to 20/20 in both eyes. Ultimately, she was found to be positive for myelin oligodendrocyte glycoprotein (MOG) antibodies, consistent with a diagnosis of MOG-associated optic neuritis. The patient's course was typical for MOG-associated optic neuritis but her peripheral retinal haemorrhages were atypical, which created diagnostic uncertainty. It is important to be aware of the possibility of retinal findings in this disease. We also review potential causes for retinal haemorrhages in optic neuritis.

Indexed as

corticosteroidsMOG-associated optic neuritisoptic nerve oedemaplasma exchangeretinal haemorrhage

Identifiers

PMID38756341
PMCPMC11095579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.