Evidence map›Paper›PMID 38756121›Full record

ArticleJPGN reports2024

Herbal and dietary supplement induced liver injury leading to hepatitis-associated severe aplastic anemia: A case report.

Rebecca Mercedes, Sanjiv Harpavat, Paula M Hertel, Ghadir Sasa, Susan Kirk, Kalyani Patel, Krupa R Mysore

Abstract readCase Reports
In one paragraph

Article in JPGN reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecca MercedesDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas USA.ORCID https://orcid.org/0000-0002-0855-090X
Sanjiv HarpavatDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas USA.
Paula M HertelDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas USA.
Ghadir SasaDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas USA.
Susan KirkDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas USA.
Kalyani PatelDepartment of Pathology and Immunology Baylor College of Medicine Houston Texas USA.
Krupa R MysoreDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas USA.ORCID https://orcid.org/0000-0001-9890-5518

Funding

Research Training in Pediatrics GastroenterolgyT32DK007664 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI DOUGLAS G BURRIN · 1991 to 2026
$8.4M
NIDDK NIH HHS T32 DK007664
6 · The paper itself

Abstract

Herbal and dietary supplements (HDS) are a common etiology of drug induced liver injury and, specifically, Herbalife® supplements have been implicated. Hepatitis associated aplastic anemia (HAAA) is a rare and potentially fatal complication after acute hepatitis characterized by pancytopenia. While there have been rare cases of HDS leading to HAAA, no cases of Herbalife® induced liver injury leading to HAAA have been reported from this specific HDS. We report a unique case of severe aplastic anemia developing after sub-fulminant liver failure associated with chronic HDS use. This case illustrates the importance of warning the public about HDS as their use continues to increase. It is not only important to recognize HDS as etiology, but also for healthcare providers to carefully monitor these patients after resolution of liver injury for the development of HAAA.

Indexed as

drug induced liver injuryherbal and dietary supplementsHerbalife®liver failure

Identifiers

PMID38756121
PMCPMC11093934

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.