Evidence map›Paper›PMID 38755626›Full record

ArticleAIDS research and therapy2024

Xpert HIV-1 qual point-of-care testing for HIV early infant diagnosis in Tanzania: experiences and perceptions of health care workers in a 2016 study.

Siriel Boniface, Anange Lwilla, Hellen Mahiga, Doreen Pamba, Otto Geisenberger, John France, Rebecca Mokeha, Lilian Njovu, Abisai Kisinda, Nyanda Elias Ntinginya and 3 more

Abstract read
In one paragraph

Article in AIDS research and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Siriel Boniface *National Institute for Medical Research, Mbeya Medical Research Center, P.O.Box 2410, Mbeya, Tanzania.
Anange Lwilla *National Institute for Medical Research, Mbeya Medical Research Center, P.O.Box 2410, Mbeya, Tanzania. alwilla@nimr-mmrc.org.
Hellen MahigaNational Institute for Medical Research, Mbeya Medical Research Center, P.O.Box 2410, Mbeya, Tanzania.
Doreen PambaNational Institute for Medical Research, Mbeya Medical Research Center, P.O.Box 2410, Mbeya, Tanzania.
Otto GeisenbergerDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany.
John FranceDepartment of Obstetrics and Gynaecology, Mbeya Zonal Referral Hospital, Mbeya, Tanzania.
Rebecca MokehaDepartment of Obstetrics and Gynaecology, Mbeya Zonal Referral Hospital, Mbeya, Tanzania.
Lilian NjovuNational Institute for Medical Research, Mbeya Medical Research Center, P.O.Box 2410, Mbeya, Tanzania.
Abisai KisindaNational Institute for Medical Research, Mbeya Medical Research Center, P.O.Box 2410, Mbeya, Tanzania.
Nyanda Elias NtinginyaNational Institute for Medical Research, Mbeya Medical Research Center, P.O.Box 2410, Mbeya, Tanzania.
Michael HoelscherGerman Center for Infection Research (DZIF), Munich, Germany.
Arne KroidlDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany.
Issa SabiNational Institute for Medical Research, Mbeya Medical Research Center, P.O.Box 2410, Mbeya, Tanzania.

Funding

German Centre for Infectious Diseases (DZIF) TTU 04.703German Centre for Infectious Diseases (DZIF) TTU 04.903
6 · The paper itself

Abstract

backgroundHIV early infant diagnosis (HEID) at the centralized laboratory faces many challenges that impact the cascade of timely HEID. Point of Care (PoC) HEID has shown to reduce test turnaround times, allow for task shifting and has the potential to reduce infant mortality. We aimed at assessing the feasibility of nurse based PoC-HEID in five facilities of Mbeya region.

methodsWe analysed data from healthcare workers at five obstetric health facilities that participated in the BABY study which enrolled mothers living with HIV and their HIV exposed infants who were followed up until 6 weeks post-delivery. Nurses and laboratory personnel were trained and performed HEID procedures using the Xpert HIV-1 Qual PoC systems. Involved personnel were interviewed on feasibility, knowledge and competency of procedures and overall impression of the use of HIV-1 Qual PoC system in clinical settings.

resultsA total of 28 health care workers (HCWs) who participated in the study between 2014 and 2016 were interviewed, 23 being nurses, 1 clinical officer, 1 lab scientist and 3 lab technicians The median age was 39.5 years. Majority of the nurses (22/24) and all lab staff were confident using Gene Xpert PoC test after being trained. None of them rated Gene Xpert handling as too complicated despite minor challenges. Five HCWs (5/24) reported power cut as the most often occurring problem. As an overall impression, all interviewees agreed on PoC HEID to be used in clinical settings however, about half of them (11/24) indicated that the PoC-HEID procedures add a burden onto their routine workload.

conclusionOverall, health care workers in our study demonstrated very good perceptions and experiences of using PoC HEID. Efforts should be invested on quality training, targeted task distribution at the clinics, continual supportive supervision and power back up mechanisms to make the wide-scale adoption of nurse based PoC HEID testing a possibility.

Indexed as

Early DiagnosisHealth PersonnelHIV-1HIV InfectionsPoint-of-Care TestingAdultAttitude of Health PersonnelFemaleHIV TestingHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMalePregnancyTanzaniaEarly infant diagnosisHIVPoint-of-care testingPrimary healthcare workersVertical HIV transmission

Identifiers

PMID38755626
PMCPMC11097447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.