ArticleInfection and immunity1985
Soluble non-cross-linked peptidoglycan polymers stimulate monocyte-macrophage inflammatory functions.
Article in Infection and immunity, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- A novel gut inflammatory rat model by laparotomic injection of peptidoglycan from Staphylococcus aureus.Archives of microbiology · 2022Article
- Neisseria gonorrhoeae Lytic Transglycosylases LtgA and LtgD Reduce Host Innate Immune Signaling through TLR2 and NOD2.ACS infectious diseases · 2017Article
- Can Enterococcal Infections Initiate Sepsis Syndrome?Current infectious disease reports · 2003Article
- The involvement of CD14 in the activation of human monocytes by peptidoglycan monomers.Mediators of inflammation · 2001Article
- Synergistic epithelial responses to endotoxin and a naturally occurring muramyl peptide.Infection and immunity · 2000Article
- Supernatants from Staphylococcus epidermidis grown in the presence of different antibiotics induce differential release of tumor necrosis factor alpha from human monocytes.Infection and immunity · 1996Article
- Evidence for lipopolysaccharide as the predominant proinflammatory mediator in supernatants of antibiotic-treated bacteria.Infection and immunity · 1994Article
- Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglycans.Infection and immunity · 1993Article
- Macrophage response to bacteria: induction of marked secretory and cellular activities by lipoteichoic acids.Infection and immunity · 1992Article
- Production of interleukin-1 but not tumor necrosis factor by human monocytes stimulated with pneumococcal cell surface components.Infection and immunity · 1989Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Soluble non-cross-linked peptidoglycan polymers are released by gram-positive bacteria when beta-lactam antibiotics are administered to humans. In this report, we show that this type of peptidoglycan can stimulate monocyte-macrophage functions that cause inflammation. Non-cross-linked peptidoglycan polymers from penicillin-treated Streptococcus faecium were purified and shown to stimulate the production of interleukin 1 by human monocytes and of colony-stimulating factors by a murine macrophage cell line. In addition, the release of plasminogen activator by human monocytes was inhibited by the soluble peptidoglycan. These in vitro results suggest that prolonged treatment with beta-lactam antibiotics, by causing the production of soluble peptidoglycan, may result in interleukin 1-mediated inflammatory reactions, excessive production of monocytes and granulocytes, and increased fibrin deposition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.