ArticleBMC geriatrics2024
Associations of CBC-Derived inflammatory indicators with sarcopenia and mortality in adults: evidence from Nhanes 1999 ∼ 2006.
Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MASLD and sarcopenia research (2012-2025): a multi-database bibliometric analysis.Frontiers in nutrition · 2026Pooled it
- The U-shaped correlation between the systemic immune-inflammation index and all-cause and cardiovascular mortality in hyperlipidemic patients: findings from NHANES 1999-2018.Annals of medicine · 2026Article
- Article
- Association of composite inflammatory indicators with osteoporosis and sarcopenia in type 2 diabetes mellitus: the mediating role of inflammation.Journal of endocrinological investigation · 2026Article
- The associations between systemic immune-inflammation index and IgE in children with allergic rhinitis: a case-control study.Pediatric research · 2026Article
- Joint association of sleep duration and physical activity with constipation: a cross-sectional study.Journal of global health · 2026Article
- Pathological changes and therapeutic strategies for sarcopenia.EFORT open reviews · 2026Review
- Association between sarcopenia and mortality in patients with osteoarthritis.Clinical rheumatology · 2026Article
- The association between sarcopenia and carotid artery plaque: a mediation analysis of inflammatory biomarkers.BMC endocrine disorders · 2026Article
- CABIT: a novel biomarkers-integrated inflammatory risk tool for ischemic heart disease developed in the USA and prospectively validated in China.Journal of translational medicine · 2026Article
- Correlation of neutrophil- and high-density lipoprotein cholesterol-related inflammatory markers with sarcopenia: Insights from a cross-sectional study.The Journal of international medical research · 2026Article
- Association between adherence to EAT-Lancet diet and risk of sarcopenia and sarcopenic obesity in adults.International journal of obesity (2005) · 2026Article
- The Role of hs-CRP and Systemic Immune-Inflammation Index in Sarcopenia and Sarcopenic Obesity in Young Populations: Results from the National Health and Nutrition Examination Survey 2015-2018.Endocrine, metabolic & immune disorders drug targets · 2026Article
- dNLR, NLR, and NMLR as differential markers for assessing severity and sepsis in emphysematous pyelonephritis.Frontiers in medicine · 2026Article
- Association between inflammatory indicators derived from preconception complete blood count and specific adverse fetal, neonatal, and pregnancy outcomes: a national cohort study.Frontiers in endocrinology · 2026Article
- Impact of systemic immune-inflammation index and systemic inflammation response index on all-cause and cause-specific mortality: a community-based cohort study.Frontiers in medicine · 2026Article
- Elevated Inflammatory Burden Index Is Association With Increased Sarcopenia: A Population-Based Study.Mediators of inflammation · 2026Article
- Comparative value of novel inflammatory indices in predicting incident carotid atherosclerosis: SIRI outperforms other markers in a general population.Frontiers in cardiovascular medicine · 2026Article
- Association Between CBC-Derived Inflammatory Indicators and 28-Day Mortality in Patients With Coronary Heart Disease and Diabetes Mellitus: A Cohort Study From the MIMIC-IV Database.Mediators of inflammation · 2026Article
- Evaluation of ten composite inflammatory indicators for sarcopenia in type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
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11 authors.
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Abstract
backgroundIt has been proposed that inflammation plays a role in the development of sarcopenia. This study aimed to investigate the links of complete blood cell count (CBC) parameters and CBC-derived inflammatory indicators with sarcopenia and mortality.
methodsData pertaining to sarcopenia were extracted from the 1999-2006 National Health and Nutrition Examination Survey (NHANES), and mortality events were ascertained through the National Death Index up to December 31, 2019. The CBC-derived inflammatory indicators assessed in this study included the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), monocyte-to-lymphocyte ratio (MLR), neutrophil-monocyte to lymphocyte ratio (NMLR), systemic inflammatory response index (SIRI), and systemic immune-inflammation index (SII). The prognostic significance of these CBC-derived inflammatory indicators was evaluated using the random survival forests (RSF) analysis.
resultsThe study encompassed a cohort of 12,689 individuals, among whom 1,725 were diagnosed with sarcopenia. Among individuals with sarcopenia, 782 experienced all-cause mortality, and 195 succumbed to cardiovascular causes. Following adjustment for confounding variables, it was observed that elevated levels of NLR, dNLR, NMLR, SIRI, and SII were associated with an increased prevalence of sarcopenia. Among participants with sarcopenia, those in the highest quartile of NLR (HR = 1.336 [1.095-1.631]), dNLR (HR = 1.274 [1.046-1.550]), MLR (HR = 1.619 [1.290-2.032]), NMLR (HR = 1.390 [1.132-1.707]), and SIRI (HR = 1.501 [1.210-1.862]) exhibited an elevated risk of all-cause mortality compared to those in the lowest quartile of these inflammation-derived indicators. These associations were similarly observed in cardiovascular mortality (HR = 1.874 [1.169-3.003] for MLR, HR = 1.838 [1.175-2.878] for SIRI). The RSF analysis indicated that MLR exhibited the highest predictive power for both all-cause and cardiovascular mortality among individuals with sarcopenia.
conclusionsOur findings underscore the association between CBC-derived inflammatory indicators and mortality in adults with sarcopenia. Of note, MLR emerged as the most robust predictor of all-cause and cardiovascular mortality in this population.
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