Evidence map›Paper›PMID 38755517›Full record

ArticleNeurochemical research2024

Prolactin is an Endogenous Antioxidant Factor in Astrocytes That Limits Oxidative Stress-Induced Astrocytic Cell Death via the STAT3/NRF2 Signaling Pathway.

Miriam Ulloa, Fernando Macías, Carmen Clapp, Gonzalo Martínez de la Escalera, Edith Arnold

Abstract read
In one paragraph

Article in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Exploring the antioxidant potential of prolactin.Frontiers in pharmacology · 2025
    Article
  7. Traumatic brain injury and prolactin.Reviews in endocrine & metabolic disorders · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Miriam UlloaInstituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, 76230, Querétaro, México.
Fernando MacíasInstituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, 76230, Querétaro, México.
Carmen ClappInstituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, 76230, Querétaro, México.
Gonzalo Martínez de la EscaleraInstituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, 76230, Querétaro, México. gmel@unam.mx.ORCID http://orcid.org/0000-0002-4309-3476
Edith ArnoldInstituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, 76230, Querétaro, México. earnoldh@gmail.com.ORCID http://orcid.org/0000-0002-9247-1939

Funding

UNAM-PAPIIT IN201621
6 · The paper itself

Abstract

Oxidative stress-induced death of neurons and astrocytes contributes to the pathogenesis of numerous neurodegenerative diseases. While significant progress has been made in identifying neuroprotective molecules against neuronal oxidative damage, little is known about their counterparts for astrocytes. Prolactin (PRL), a hormone known to stimulate astroglial proliferation, viability, and cytokine expression, exhibits antioxidant effects in neurons. However, its role in protecting astrocytes from oxidative stress remains unexplored. Here, we investigated the effect of PRL against hydrogen peroxide (H

Indexed as

AntioxidantsAstrocytesCell DeathHydrogen PeroxideNF-E2-Related Factor 2Oxidative StressProlactinSignal TransductionSTAT3 Transcription FactorAnimalsCells, CulturedMiceRatsAntioxidantsHydrogen PeroxideNfe2l2 protein, mouseNF-E2-Related Factor 2ProlactinStat3 protein, mouseSTAT3 Transcription FactorAntioxidantAstrocytesNRF2Oxidative stressProlactinSTAT3

Identifiers

PMID38755517
PMCPMC11144156

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.