ArticleNature communications2024
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
Abstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Interferon-induced transmembrane (IFITM) proteins at the tumour-immune interface: A four-axis framework for their context-dependent roles.Clinical and translational medicine · 2026Review
- Single-cell transcriptomic analysis deciphers heterogeneity and transcriptional regulatory programs of sepsis with different prognosis.Biology direct · 2026Article
- Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.Nature communications · 2026Article
- Human pneumovirus induces IFN-dependent expression of the immune-responsive gene 1 and is inhibited by 4-octyl itaconate in human macrophages.NAR molecular medicine · 2026Article
- Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections.Genes and immunity · 2026Review
- N6-methyladenosine as a potential epitranscriptomic immune rheostat during SARS-CoV-2 infection.Frontiers in immunology · 2026Review
- Bench evaluation of six non-invasive ventilation home ventilators: comparison with an ICU ventilator and unsupervised clustering.BMJ open respiratory research · 2025Article
- Distinctive Temporal Profiles of Interferon-Stimulated Genes in Natural Infection, Viral Challenge, and Vaccination.Viruses · 2025Article
- APOE genotype confers context-dependent neurovascular vulnerability in immune-vascularized human forebrain organoids.bioRxiv : the preprint server for biology · 2025Article
- Machine-learning analysis identifies "elite" viral controllers with increased survival and homeostatic responses in critical COVID-19.Clinical and translational medicine · 2025Article
- Transcriptomic profiling of severe and critical COVID-19 patients reveals alterations in expression, splicing and polyadenylation.Scientific reports · 2025Article
- mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-γ and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity.Journal of virology · 2025Article
- Granulocyte colony-stimulating factor protects against acute systemic alphavirus disease in a type I IFN-dependent manner.Frontiers in immunology · 2025Article
- Immune Biomarkers at Birth Predict Lower Respiratory Tract Infection Risk in a Large Birth Cohort.Pathogens (Basel, Switzerland) · 2024Article
- Multiple Mechanisms of Action of SulfodyneAntioxidants (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors.
Elsa Brunet-Ratnasingham *Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Sacha Morin *Department of Computer Science and Operations Research, Université de Montréal, Montreal, QC, Canada.
Haley E Randolph *Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2044-1180
Marjorie LabrecqueCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Justin BélairDepartment of Mathematics and Statistics, Université de Montréal, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-4219-1824
Raphaël Lima-BarbosaDepartment of Mathematics and Statistics, Université de Montréal, Montreal, QC, Canada.
Amélie PagliuzzaCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Lorie MarchittoCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Michael HultströmAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. michael.hultstrom@mcb.uu.se.ORCID http://orcid.org/0000-0003-4675-1099
Julia NiesslCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-8852-1924
Rose CloutierCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Alina M Sreng FloresCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Nathalie BrassardCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-4320-9416
Mehdi BenlarbiCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Jérémie PrévostCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Shilei DingCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Sai Priya AnandCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Gérémy SannierCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-7956-4463
Amanda MarksDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-3961-8831
Dick WågsäterIntegrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Eric BarekeCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Hugo ZebergDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7118-1249
Miklos LipcseyAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-1976-4129
Robert FrithiofAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-2278-7951
Anders LarssonClinical Chemistry, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3161-0402
Sirui ZhouLady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-4963-0815
Tomoko NakanishiLady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-9510-5646
David MorrisonLady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-8380-3615
Dani VezinaCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-0780-8593
Catherine BourassaCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Gabrielle Gendron-LepageCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Halima MedjahedCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Floriane PointCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Jonathan RichardCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Catherine LarochelleCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-8724-4782
Alexandre PratCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-6188-0580
Janet L CunninghamDepartment of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-7876-7779
Nathalie ArbourCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-3718-1584
Madeleine DurandCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
J Brent RichardsDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-3746-9086
Kevin MoonDepartment of Mathematics and Statistics, Utah State University, Logan, UT, USA.
Nicolas ChomontCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-9747-5018
Andrés FinziCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Martine TétreaultCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Luis BarreiroCommittee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9456-367X
Guy WolfDepartment of Computer Science and Operations Research, Université de Montréal, Montreal, QC, Canada. guy.wolf@umontreal.ca.ORCID http://orcid.org/0000-0002-6740-059X
Daniel E KaufmannCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada. daniel.kaufmann@chuv.ch.ORCID http://orcid.org/0000-0003-4467-136X
Funding
Finding emergent structure in multi-sample biological data with the dual geometry of cells and features R01GM135929 · NIGMS · MICHIGAN STATE UNIVERSITY · PI BROWN, EDWARD · 2019 to 2022
$1.4MGenetic determinants of inter-individual variation in the dynamic transcriptional innate immune response to Mycobacterium tuberculosisF31HL156419 · NHLBI · UNIVERSITY OF CHICAGO · PI RANDOLPH, HALEY ELIZABETH · 2021 to 2022
$93kamfAR, The Foundation for AIDS Research (amfAR) 110068-68-RGCVCanada Foundation for Innovation (Fondation canadienne pour l'innovation) 37521Canada Foundation for Innovation (Fondation canadienne pour l'innovation) 41027Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre) VR2-173203NHLBI NIH HHS F31 HL156419NIGMS NIH HHS R01 GM135929
Abstract
Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized patients with COVID-19. Integrated analysis using k-means reveals four patient clusters in a discovery cohort: mechanically ventilated critically-ill cases are subdivided into good prognosis and high-fatality clusters (reproduced in a validation cohort), while non-critical survivors segregate into high and low early antibody responders. Only the high-fatality cluster is enriched for transcriptomic signatures associated with COVID-19 severity, and each cluster has distinct RBD-specific antibody elicitation kinetics. Both critical and non-critical clusters with delayed antibody responses exhibit sustained IFN signatures, which negatively correlate with contemporaneous RBD-specific IgG levels and absolute SARS-CoV-2-specific B and CD4
Indexed as
Antibodies, ViralCOVID-19InterferonsSARS-CoV-2Signal TransductionAdultAgedCD4-Positive T-LymphocytesFemaleHumansImmunoglobulin GMaleMiddle AgedSpike Glycoprotein, CoronavirusAntibodies, ViralImmunoglobulin GInterferonsSpike Glycoprotein, Coronavirus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.