Evidence map›Paper›PMID 38755170›Full record

ArticleScientific reports2024

Homocysteine thiolactone and other sulfur-containing amino acid metabolites are associated with fibrin clot properties and the risk of ischemic stroke.

Marta Sikora, Ewa Bretes, Joanna Perła-Kaján, Olga Utyro, Kamila Borowczyk, Justyna Piechocka, Rafał Głowacki, Izabela Wojtasz, Radosław Kaźmierski, Hieronim Jakubowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Homocysteinylation of Fibrinogen: A Post-Translational Link to Thrombosis.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marta SikoraEuropean Centre for Bioinformatics and Genomics, Institute of Bioorganic Chemistry, 61-704, Poznań, Poland.
Ewa BretesDepartment of Biochemistry and Biotechnology, Poznań University of Life Sciences, 60-632, Poznań, Poland.
Joanna Perła-KajánDepartment of Biochemistry and Biotechnology, Poznań University of Life Sciences, 60-632, Poznań, Poland.
Olga UtyroDepartment of Biochemistry and Biotechnology, Poznań University of Life Sciences, 60-632, Poznań, Poland.
Kamila BorowczykFaculty of Chemistry, Department of Environmental Chemistry, University of Łódź, 90-236, Łódź, Poland.
Justyna PiechockaFaculty of Chemistry, Department of Environmental Chemistry, University of Łódź, 90-236, Łódź, Poland.
Rafał GłowackiFaculty of Chemistry, Department of Environmental Chemistry, University of Łódź, 90-236, Łódź, Poland.
Izabela WojtaszMedicover, 61-131, Poznań, Poland.
Radosław KaźmierskiDepartment of Neurology, Collegium Medicum, University of Zielona Góra, 65-046, Zielona Góra, Poland.
Hieronim JakubowskiDepartment of Biochemistry and Biotechnology, Poznań University of Life Sciences, 60-632, Poznań, Poland. jakubows@rutgers.edu.

Funding

American Heart Association 17GRNT32910002Narodowe Centrum Nauki 2017/27/B/ST4/01476Narodowe Centrum Nauki 2018/29/B/NZ4/00771
6 · The paper itself

Abstract

Homocysteine (Hcy) and Hcy-thiolactone (HTL) affect fibrin clot properties and are linked to cardiovascular disease. Factors that influence fibrin clot properties and stroke are not fully understood. To study sulfur-containing amino acid metabolites, fibrin clot lysis time (CLT) and maximum absorbance (Abs

Indexed as

FibrinHomocysteineIschemic StrokeAdultAgedAged, 80 and overAmino AcidsAmino Acids, SulfurCase-Control StudiesFemaleFibrin Clot Lysis TimeHumansMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedRisk FactorsAmino AcidsAmino Acids, SulfurFibrinHomocysteinehomocysteine thiolactoneMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanFibrin clot propertiesHomocysteine thiolactoneStrokeSulfur amino acids

Identifiers

PMID38755170
PMCPMC11099160

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.