ArticleAnimal bioscience2024
Effect of cholesterol-loaded cyclodextrin treatment on boar sperm cryopreservation.
Article in Animal bioscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Cryoprotective effects of cholesterol-loaded cyclodextrin and iodixanol on ram sperm: assessment of post-thaw quality and in vitro fertilization outcomes.BMC veterinary research · 2026Article
- Cross-species multi-omic analyses of great ape ejaculates reveal novel strategies for enhancing sperm cryopreservation in Bornean orangutan (Pongo pygmaeus).Zoological letters · 2026Article
- The effect of combined cryoprotectants on the cryotolerance of boar sperm.Animal bioscience · 2025Article
- Mitoquinone Can Effectively Improve the Quality of Thawed Boar Sperm.Animals : an open access journal from MDPI · 2025Article
- Effects of hesperidin and ascorbic acid combination on boar sperm quality during cryopreservation.Frontiers in veterinary science · 2025Article
- Pyrroroquinoline Quinone (PQQ) Improves the Quality of Holstein Bull Semen during Cryopreservation.Animals : an open access journal from MDPI · 2024Article
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Authors and funding
10 authors.
Funding
Abstract
objectiveThis study investigated the efficacy of different concentrations of cholesterolloaded cyclodextrin (CLC) on cryopreservation in boar sperm quality.
methodsIn this study, we treated boar sperm with different concentrations of CLC before freezing and analyzed the sperm cholesterol concentration, plasma membrane, acrosome integrity rate and total motility rate before and after freeze-thawing. We also investigated the levels of reactive oxygen species (ROS), malondialdehyde (MDA), adenosine triphosphate (ATP), and structural- and oxidative-damage related proteins in all groups after thawing.
resultsThe results revealed that the cholesterol concentration of the CLC-treated groups was higher than that of the control group, both before freezing and after thawing (p<0.05). The plasma membrane integrity rate, acrosome integrity rate, and total motility rate of sperm were also enhanced after thawing in the CLC-treated group (all p<0.05). Moreover, ROS and MDA production and ATP loss were reduced in CLC-treated sperm during freezing and thawing (p<0.05). Finally, CLC pretreatment partially prevented the consumption of various proteins involved in metabolism including capping actin protein of muscle Z-line subunit beta (CAPZB), heat shock protein 90 alpha family class A member 1 (HSP90AA1) and phosphoglycerate mutase 2 (PGAM2) (p<0.05).
conclusionThe CLC treatment increased cholesterol concentration and decreased structural injury and oxidative damage during boar sperm freezing and thawing, improving the efficacy of sperm cryopreservation in boar.
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