Evidence map›Paper›PMID 38754415›Full record

ReviewNeuron2024

Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex.

Daniela J Di Bella, Nuria Domínguez-Iturza, Juliana R Brown, Paola Arlotta

Abstract readReview
In one paragraph

Review in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
  6. Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development.Advances in experimental medicine and biology · 2026
    Review
  7. Article
  8. Article
  9. Establishing a continuum of cell types in the visual cortex.bioRxiv : the preprint server for biology · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniela J Di BellaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: daniela_dibella@fas.harvard.edu.
Nuria Domínguez-IturzaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: nuriadomingueziturza@fas.harvard.edu.
Juliana R BrownDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Paola ArlottaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: paola_arlotta@harvard.edu.

Funding

Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI HUANG, Z JOSH · 2017 to 2021
$64.5M
Comprehensive single-cell atlas of the developing mouse brainU01MH130962 · NIMH · HARVARD UNIVERSITY · PI Paola Arlotta, Tomasz Nowakowski · 2022 to 2026
$33.3M
Res Support CoreP50MH094271 · NIMH · HARVARD UNIVERSITY · PI HENSCH, TAKAO K · 2011 to 2022
$18.6M
Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortexUF1MH130701 · NIMH · BROAD INSTITUTE, INC. · PI ARLOTTA, PAOLA, DEVERMAN, BENJAMIN E · 2022 to 2022
$10.7M
Modeling ASD-linked genetic mutations in 3D human brain organoidsR01MH112940 · NIMH · HARVARD UNIVERSITY · PI Paola Arlotta · 2018 to 2026
$5.2M
Molecular principles of neuronal maturation and integration in the adult and aging brainR01NS103758 · NINDS · HARVARD UNIVERSITY · PI ARLOTTA, PAOLA, SCHINDER, ALEJANDRO FABIAN · 2018 to 2022
$2.7M
Neuron-Oligodendrocyte Communication Underlying Myelin Distribution in the NeocortexR01NS128117 · NINDS · HARVARD UNIVERSITY · PI Paola Arlotta · 2022 to 2026
$2.1M
NIMH NIH HHS P50 MH094271NIMH NIH HHS R01 MH112940NIMH NIH HHS U01 MH130962NIMH NIH HHS U19 MH114821NIMH NIH HHS UF1 MH130701NINDS NIH HHS R01 NS103758NINDS NIH HHS R01 NS128117
6 · The paper itself

Abstract

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the immense diversity and complexity of cell types found in the cerebral cortex, neuroscience has been challenged and inspired to understand how these diverse cells are generated and how they interact with each other to orchestrate the development of this remarkable tissue. Some fundamental questions drive the field's quest to understand cortical development: what are the mechanistic principles that govern the emergence of neuronal diversity? How do extrinsic and intrinsic signals integrate with physical forces and activity to shape cell identity? How do the diverse populations of neurons and glia influence each other during development to guarantee proper integration and function? The advent of powerful new technologies to profile and perturb cortical development at unprecedented resolution and across a variety of modalities has offered a new opportunity to integrate past knowledge with brand new data. Here, we review some of this progress using cortical excitatory projection neurons as a system to draw out general principles of cell diversification and the role of cell-cell interactions during cortical development.

Indexed as

Cerebral CortexNeuronsAnimalsHumansNeurogenesiscell-cell interactionscortical developmentextrinsic signalinggene regulationneuronal specification

Identifiers

PMID38754415
PMCPMC11771131

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.