Evidence map›Paper›PMID 38754414›Full record

ArticleNeuron2024

Nr4a1 regulates cell-specific transcriptional programs in inhibitory GABAergic interneurons.

Min Huang, Simon Pieraut, Jasmine Cao, Filip de Souza Polli, Vincenzo Roncace, Gloria Shen, Carlos Ramos-Medina, HeeYang Lee, Anton Maximov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. NR4A1 limits CD8Research square · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Min HuangDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA; The Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Simon PierautDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jasmine CaoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Filip de Souza PolliDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Vincenzo RoncaceDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Gloria ShenDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Carlos Ramos-MedinaDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
HeeYang LeeDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA; The Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Anton MaximovDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; The Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: amaximov@scripps.edu.

Funding

Transcriptional Control of Synaptic Plasticity by Class IIa HDACsR01NS087026 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI MAXIMOV, ANTON · 2015 to 2024
$5.4M
Molecular mechanisms of structural plasticity of inhibitory GABAergic interneuronsR01MH118442 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI MAXIMOV, ANTON · 2019 to 2023
$3.4M
New approaches for chemical-genetic targeting of specific circuits and cell types in the mammalian brainRF1MH123224 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI MAXIMOV, ANTON · 2020 to 2020
$2.7M
Development of new methods for drug-inducible control of gene expression in model organismsR01GM117049 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI MAXIMOV, ANTON · 2017 to 2020
$1.7M
NIGMS NIH HHS R01 GM117049NIMH NIH HHS R01 MH118442NIMH NIH HHS RF1 MH123224NINDS NIH HHS R01 NS087026
6 · The paper itself

Abstract

The patterns of synaptic connectivity and physiological properties of diverse neuron types are shaped by distinct gene sets. Our study demonstrates that, in the mouse forebrain, the transcriptional profiles of inhibitory GABAergic interneurons are regulated by Nr4a1, an orphan nuclear receptor whose expression is transiently induced by sensory experiences and is required for normal learning. Nr4a1 exerts contrasting effects on the local axonal wiring of parvalbumin- and somatostatin-positive interneurons, which innervate different subcellular domains of their postsynaptic partners. The loss of Nr4a1 activity in these interneurons results in bidirectional, cell-type-specific transcriptional switches across multiple gene families, including those involved in surface adhesion and repulsion. Our findings reveal that combinatorial synaptic organizing codes are surprisingly flexible and highlight a mechanism by which inducible transcription factors can influence neural circuit structure and function.

Indexed as

GABAergic NeuronsInterneuronsNuclear Receptor Subfamily 4, Group A, Member 1AnimalsMaleMiceMice, KnockoutParvalbuminsSomatostatinSynapsesNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1ParvalbuminsSomatostatinconnectivityGABAergic interneuronhippocampusimmediate-early geneinhibitionmemoryNr4a1sensory experiencesynapsetranscription

Identifiers

PMID38754414
PMCPMC11189749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.