ReviewNeuron2024
Thalamic contributions to the state and contents of consciousness.
Review in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.Frontiers in neurology · 2025Pooled it
- Lonesome No More: The Associative Thalamus and the Feeling of Being Alone.Biological psychiatry global open science · 2026Article
- Thalamic modulation of cortical linearity across arousal states.Science advances · 2026Article
- Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- The Central Medial Thalamus Serves as a Critical Hub for Preserved Arousability During Dexmedetomidine Sedation.Neuroscience bulletin · 2026Article
- Thalamic oscillations distinguish natural states of consciousness in humans.Nature human behaviour · 2026Article
- Review
- Thalamocortical orchestration of human theory of mind.bioRxiv : the preprint server for biology · 2026Article
- Metabotropic Glutamatergic Signaling Adaptively Controls Trans-thalamic Communication.bioRxiv : the preprint server for biology · 2026Article
- Advances in local field potential research in prolonged disorders of consciousness: a narrative review.Chinese neurosurgical journal · 2026Review
- Temporal Interference Stimulation of Centromedian-Parafascicular Complex in Disorders of Consciousness: A Pilot Study.Annals of clinical and translational neurology · 2026Article
- Molecular genetic influences on sustained attention and executive processes and their links with psychopathology in the AFFECT study.Molecular psychiatry · 2026Article
- Clusters in Thalamic iEEG Spectral Features Reveal Sleep/Wake Differences Over Time.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026Article
- A computational architecture incorporating shallow brain networks: integrating parallel cortical and subcortical processing.Current research in neurobiology · 2026Article
- Toward a Neurobiological Model of Gestalt Confluence: Thalamocortical Integration as a Hypothetical Framework for Contact Interruption.Brain sciences · 2026Article
- Esketamine Preserves Network Connectivity and Promotes Recovery in Consciousness Disorders.CNS neuroscience & therapeutics · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.Depression and anxiety · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Consciousness can be conceptualized as varying along at least two dimensions: the global state of consciousness and the content of conscious experience. Here, we highlight the cellular and systems-level contributions of the thalamus to conscious state and then argue for thalamic contributions to conscious content, including the integrated, segregated, and continuous nature of our experience. We underscore vital, yet distinct roles for core- and matrix-type thalamic neurons. Through reciprocal interactions with deep-layer cortical neurons, matrix neurons support wakefulness and determine perceptual thresholds, whereas the cortical interactions of core neurons maintain content and enable perceptual constancy. We further propose that conscious integration, segregation, and continuity depend on the convergent nature of corticothalamic projections enabling dimensionality reduction, a thalamic reticular nucleus-mediated divisive normalization-like process, and sustained coherent activity in thalamocortical loops, respectively. Overall, we conclude that the thalamus plays a central topological role in brain structures controlling conscious experience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.