Evidence map›Paper›PMID 38754245›Full record

ArticleEnvironment international2024

Associations of street-view greenspace with Parkinson's disease hospitalizations in an open cohort of elderly US Medicare beneficiaries.

Jochem O Klompmaker, Daniel Mork, Antonella Zanobetti, Danielle Braun, Steve Hankey, Jaime E Hart, Perry Hystad, Marcia Pescador Jimenez, Francine Laden, Andrew Larkin and 6 more

Abstract read
In one paragraph

Article in Environment international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. PMEnvironmental health perspectives · 2026
    Article
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. GPS-based street-view greenspace exposure and wearable assessed physical activity in a prospective cohort of US women.The international journal of behavioral nutrition and physical activity · 2025
    Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jochem O KlompmakerDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: jklompmaker@hsph.harvard.edu.
Daniel MorkDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Antonella ZanobettiDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Danielle BraunDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Steve HankeyUrban Affairs and Planning (UAP), School of Public and International Affairs, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Jaime E HartDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Perry HystadCollege of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.
Marcia Pescador JimenezDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Francine LadenDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Andrew LarkinCollege of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.
Pi-I Debby LinDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Esra SuelFaculty of the Built Environment, University College London, London, England.
Li YiDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Wenwen ZhangEdward J Bloustein School of Planning and Public Policy, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Scott W DelaneyDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Peter JamesDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
National Cohort Studies of Alzheimer's Disease, Related Dementias and Air PollutionR01AG066793 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2020 to 2025
$4.2M
Built Environment Assessment through Computer visiON (BEACON): Applying Deep Learning to Street-Level and Satellite Images to Estimate Built Environment Effects on Cardiovascular HealthR01HL150119 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JAMES, PETER · 2020 to 2024
$3.9M
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and SusceptibilityR01ES028033 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LADEN, FRANCINE · 2018 to 2022
$3.5M
(R01 Transfer) Characterizing the link between multiple environmental exposures and Parkinsons disease exacerbationR01ES034373 · NIEHS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Danielle Braun, Antonella Zanobetti · 2022 to 2026
$2.9M
NHLBI NIH HHS R01 HL150119NIA NIH HHS R01 AG066793NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES028033NIEHS NIH HHS R01 ES034373
6 · The paper itself

Abstract

introductionProtective associations of greenspace with Parkinson's disease (PD) have been observed in some studies. Visual exposure to greenspace seems to be important for some of the proposed pathways underlying these associations. However, most studies use overhead-view measures (e.g., satellite imagery, land-classification data) that do not capture street-view greenspace and cannot distinguish between specific greenspace types. We aimed to evaluate associations of street-view greenspace measures with hospitalizations with a PD diagnosis code (PD-involved hospitalization).

methodsWe created an open cohort of about 45.6 million Medicare fee-for-service beneficiaries aged 65 + years living in core based statistical areas (i.e. non-rural areas) in the contiguous US (2007-2016). We obtained 350 million Google Street View images across the US and applied deep learning algorithms to identify percentages of specific greenspace features in each image, including trees, grass, and other green features (i.e., plants, flowers, fields). We assessed yearly average street-view greenspace features for each ZIP code. A Cox-equivalent re-parameterized Poisson model adjusted for potential confounders (i.e. age, race/ethnicity, socioeconomic status) was used to evaluate associations with first PD-involved hospitalization.

resultsThere were 506,899 first PD-involved hospitalizations over 254,917,192 person-years of follow-up. We found a hazard ratio (95% confidence interval) of 0.96 (0.95, 0.96) per interquartile range (IQR) increase for trees and a HR of 0.97 (0.96, 0.97) per IQR increase for other green features. In contrast, we found a HR of 1.06 (1.04, 1.07) per IQR increase for grass. Associations of trees were generally stronger for low-income (i.e. Medicaid eligible) individuals, Black individuals, and in areas with a lower median household income and a higher population density.

conclusionIncreasing exposure to trees and other green features may reduce PD-involved hospitalizations, while increasing exposure to grass may increase hospitalizations. The protective associations may be stronger for marginalized individuals and individuals living in densely populated areas.

Indexed as

HospitalizationMedicareParkinson DiseaseAgedAged, 80 and overCohort StudiesFemaleHumansMaleUnited StatesBuilt EnvironmentNeurological DisordersParkinson’s DiseaseStreet-View GreenspaceVisual Exposure

Identifiers

PMID38754245
PMCPMC11199351

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.