ArticleScience translational medicine2024
Heterologous prime-boost vaccination drives early maturation of HIV broadly neutralizing antibody precursors in humanized mice.
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Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
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Who cites it
54 citing papers in PubMed.
- Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans.Science (New York, N.Y.) · 2025Trial
- Precise targeting of HIV broadly neutralizing antibody precursors in humans.Science (New York, N.Y.) · 2025Trial
- Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial.Science translational medicine · 2025Trial
- DNA-based vaccines: Advances, applications, and future prospects.Genes & diseases · 2026Review
- Exploring the potential of mRNA vaccines in combatting communicable and non-communicable diseases in low-income and lower-middle-income countries.Annals of medicine and surgery (2012) · 2026Review
- Article
- Developing Antiviral Vaccines Based on AttenuatedPathogens (Basel, Switzerland) · 2026Review
- Learned young: HIV-1 germline-targeting vaccination in infants.Current opinion in HIV and AIDS · 2026Review
- Article
- Rapid boosting increases germinal center responses to sequential vaccines.Nature immunology · 2026Article
- Article
- Diverse germline-targeting HIV Env immunogens select for distinct mutations in the same knock-in mice B cell receptors.Nature communications · 2026Article
- Atomic layer deposition for core-shell microparticle vaccines enabling programmable antigen delivery to lymph nodes enhance humoral immune responses.bioRxiv : the preprint server for biology · 2026Article
- Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model.PLoS pathogens · 2026Article
- Recent advances in HIV-1 envelope-based vaccine designs for guiding broadly neutralizing antibody response.Journal of virology · 2026Review
- Heterologous Prime-Boost Vaccination with GRA35-Encoding DNA and mRNA Vaccines Enhances Protective Immunity AgainstMicroorganisms · 2026Article
- Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.Immunity · 2026Article
- Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV.PLoS pathogens · 2026Article
- Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading.Immunity · 2026Article
Corrections and comments
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Authors and funding
37 authors.
Christopher A CottrellDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-3364-3083
Xiaozhen HuDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-3890-0533
Jeong Hyun LeeDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-7371-845X
Patrick SkogDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-5759-5071
Sai LuoHHMI, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-7362-5445
Claudia T FlynnDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.
Katherine R McKenneyIAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.
Jonathan HurtadoDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-4145-7042
Oleksandr KalyuzhniyDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-5273-1951
Alessia LiguoriDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-8606-574X
Jordan R WillisDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-0135-5263
Elise LandaisDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-8183-5565
Sebastian RaemischDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-1801-4983
Xuejun ChenVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-9192-0440
Sabyasachi BabooDepartment of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-4547-5160
Sunny HimansuModerna Therapeutics, Cambridge, MA 02139, USA.ORCID 0000-0002-7954-9674
Jolene K DiedrichDepartment of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-6489-4558
Hongying DuanVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-0075-9493
Cheng ChengVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3837-9293
Torben SchiffnerDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.
Daniel L V BaderDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-7731-0494
Daniel W KulpDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-0527-3804
Ryan TingleDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-2874-7010
Erik GeorgesonDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-5137-4625
Saman EskandarzadehDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-0671-0770
Nushin AlaviDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-3848-6280
Danny LuDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-2340-3377
Troy SincombDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-4556-649X
Michael KubitzDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.
Tina-Marie MullenDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-6150-8084
John R YatesDepartment of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-5267-1672
James C PaulsonDepartment of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-4589-5322
John R MascolaVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5293-4695
Frederick W AltHHMI, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-0583-1271
Bryan BrineyDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-9535-2866
Devin SokDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-9354-1740
William R SchiefDepartment of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-1120-0150
Funding
Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6MVirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SONIA JAIN · 1994 to 2026
$78.4MHIV/AIDS Vaccine and Antibody DevelopmentZICAI005002 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHENG, CHENG · 2019 to 2025
$17.6MThe Multi-omics Vaccine Evaluation (MOVE) ConsortiumP01AI177683 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Bryan Briney · 2023 to 2026
$9.0MNIAID NIH HHS P01 AI177683NIAID NIH HHS P30 AI036214NIAID NIH HHS UM1 AI144462
Abstract
A protective HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs). Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with AS01
Indexed as
AIDS VaccinesAntibodies, NeutralizingHIV AntibodiesAnimalsBroadly Neutralizing AntibodiesHIV-1HIV InfectionsHumansImmunization, SecondaryMiceVaccinationAIDS VaccinesAntibodies, NeutralizingBroadly Neutralizing AntibodiesHIV Antibodies
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.