Evidence map›Paper›PMID 38753738›Full record

ArticleAIDS research and human retroviruses2024

The Global Impact of Diversifying PrEP Options: Results of an International Discrete Choice Experiment of Existing and Potential PrEP Strategies with Gay and Bisexual Men and Physicians.

Christine Tagliaferri Rael, Rebecca Giguere, Ewa Bryndza Tfaily, Sara Sutton, Elizabeth Horn, Robert J Schieffer, Craig Hendrix, Richard T D'Aquila, Thomas J Hope

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christine Tagliaferri RaelCollege of Nursing, University of Colorado, Aurora, Colorado, USA.ORCID 0000-0002-6303-3809
Rebecca GiguereHIV Center for Clinical and Behavioral Studies, NYSPI/Columbia University, New York, New York, USA.
Ewa Bryndza TfailyDepartment of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sara SuttonDecision Analyst, Arlington, Texas, USA.
Elizabeth HornDecision Analyst, Arlington, Texas, USA.
Robert J SchiefferKellogg School of Management, Northwestern University, Evanston, Illinois, USA.
Craig HendrixDivision of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Richard T D'AquilaDivision of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Thomas J HopeDepartment of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0001-7183-8319

Funding

Sustained Long Acting Prevention Against HIV Program OperationUM1AI120184 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOPE, THOMAS, KISER, PATRICK FRANKLIN · 2015 to 2019
$17.9M
Supplement: Developing Tailored Delivery and Adherence Interventions for use of Long-Acting Biomedical HIV Prevention Strategies by Transgender WomenK01MH115785 · NIMH · UNIVERSITY OF COLORADO DENVER · PI RAEL, CHRISTINE TAGLIAFERRI · 2018 to 2022
$767k
NIAID NIH HHS UM1 AI120184NIMH NIH HHS K01 MH115785
6 · The paper itself

Abstract

To improve current and future use of existing (oral, injectable) and potential future (implants, douches) pre-exposure prophylaxis (PrEP) products, we must understand product preferences relative to one another, among gay and bisexual men (GBM), and physicians who prescribe PrEP. We completed an online discrete choice experiment (DCE) with separate groups of GBM and/or physicians from the United States, South Africa, Spain, and Thailand. Participants were presented information on PrEP products, including daily pills, event-driven pills (2-1-1 regimen), injections, subdermal implants (dissolvable, removable), and rectal douches. Next, they completed a choice exercise in which they were shown 10 screens, each presenting 3 of the aforementioned products at a time with 11 attributes for physicians and 10 attributes for GBM. For the attributes that were not constant, one level was shown per screen for each product. Participants selected the product they preferred most and rated their likelihood to select (GBM) or recommend (physicians) that product. Data were modeled using hierarchical Bayes estimation; resulting model coefficients were used to develop attribute importance measures and product preferences. For GBM across all countries, if all aforementioned PrEP products were on the market at the same time, over 90% of GBM would use some form of PrEP; 100% of physicians would recommend at least one of the PrEP products. There were variations in product preference by country. GBM in the United States and Thailand preferred the injection (21.7%, 22.9%, respectively), while the dissolvable implant was preferred in South Africa and Spain (19.9%, 19.8%, respectively). In the United States, South Africa, and Spain (where physician data were available), physicians were most likely to recommend the dissolvable implant (37.2%, 40.6%, 38.3%, respectively).

Indexed as

PhysiciansPre-Exposure ProphylaxisAdultAnti-HIV AgentsChoice BehaviorHIV InfectionsHomosexuality, MaleHumansMaleMiddle AgedSexual and Gender MinoritiesSouth AfricaSpainThailandUnited StatesYoung AdultAnti-HIV Agentsdiscrete choice modelHIV preventionMSMPrEP

Identifiers

PMID38753738
PMCPMC11693963

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.