ArticleCirculation. Arrhythmia and electrophysiology2024
Preclinical Study of Pulsed Field Ablation of Difficult Ventricular Targets: Intracavitary Mobile Structures, Interventricular Septum, and Left Ventricular Free Wall.
Article in Circulation. Arrhythmia and electrophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ventricular pulsed field ablation from bench to bedside: preclinical and clinical evidence from a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Pooled it
- Pulsed Field Ablation for Ventricular Arrhythmias: A Systematic Review and Single-Arm Meta-Analysis.Pacing and clinical electrophysiology : PACE · 2026Pooled it
- Seeing Beyond the Surface: ECG Clues of Multilayer Arrhythmogenic Substrate.JACC. Case reports · 2026Article
- Iatrogenic ventricular septal defect following papillary muscle premature ventricular contraction ablation: a case report.European heart journal. Case reports · 2026Article
- Nonidiopathic papillary muscle ventricular arrhythmia ablation using the lattice-tip catheter: A case series.HeartRhythm case reports · 2026Article
- Timing of Catheter Ablation for Ventricular Tachycardia in Ischemic Cardiomyopathy: Evidence, Mechanisms, and the Emerging Role of Timely ICD-Guided Intervention.Journal of cardiovascular electrophysiology · 2026Review
- Potential role of a novel dual energy lattice-tip catheter in re-ablation of recurrent premature ventricular contractions: a case series.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Pulsed Field Ablation for Atrial Fibrillation in Japan: Current Status and Future Perspectives.Circulation reports · 2026Review
- Very High-Power Short-Duration Ablation for Premature Ventricular Complexes From Sites With Suboptimal Catheter Stability.Journal of cardiovascular electrophysiology · 2026Article
- Pulmonary vein isolation and beyond: Feasibility and acute outcomes of the lattice-tip dual-energy catheter for complex ablations.Heart rhythm O2 · 2026Article
- Pulsed Field Ablation for the Treatment of Ventricular Arrhythmias Using a Focal, Contact-Force Sensing Catheter: A Single-Center Case Series and Review.Journal of cardiovascular development and disease · 2026Article
- Ablation Methods and Catheter Settings for Ventricular Tachycardia Ablation: A Bench to Bedside Review: Part 2.Arrhythmia & electrophysiology review · 2026Review
- Pulsed field ablation for ventricular arrhythmias: From mechanistic foundations to clinical translation.Heart rhythm O2 · 2026Review
- Endocardial and epicardial pulsed field ablation for the treatment of therapy refractory ventricular tachycardia following failed radiofrequency ablation.HeartRhythm case reports · 2026Article
- Pulsed field ablation of ventricular arrhythmias arising from intracavitary structures: insights from a clinical case series.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Safety and efficacy of a lattice-tip catheter for ventricular arrhythmia ablation: the AFFERA Ventricular Arrhythmia Ablation Registry (AVAAR).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Use of a Focal Pulsed Field Ablation Catheter to Target Premature Ventricular Contractions From the Papillary Muscle.JACC. Case reports · 2025Article
- De novo ablation of premature ventricular complexes originating from posteromedial papillary muscle with pulsed-field energy using a Pentaspline catheter: The first case series in the United States.HeartRhythm case reports · 2025Article
- Biophysics and Clinical Effectiveness of Irreversible Electroporation for Catheter Ablation of Atrial Fibrillation.Journal of cardiovascular development and disease · 2025Review
- De novo ventricular tachycardia ablation with stacked pulsed-field and radiofrequency energy via a dual-energy lattice-tipped catheter.HeartRhythm case reports · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndocardial catheter-based pulsed field ablation (PFA) of the ventricular myocardium is promising. However, little is known about PFA's ability to target intracavitary structures, epicardium, and ways to achieve transmural lesions across thick ventricular tissue.
methodsA lattice-tip catheter was used to deliver biphasic monopolar PFA to swine ventricles under general anesthesia, with electroanatomical mapping, fluoroscopy and intracardiac echocardiography guidance. We conducted experiments to assess the feasibility and safety of repetitive monopolar PFA applications to ablate (1) intracavitary papillary muscles and moderator bands, (2) epicardial targets, and (3) bipolar PFA for midmyocardial targets in the interventricular septum and left ventricular free wall.
results(1) Papillary muscles (n=13) were successfully ablated and then evaluated at 2, 7, and 21 days. Nine lesions with stable contact measured 18.3±2.4 mm long, 15.3±1.5 mm wide, and 5.8±1.0 mm deep at 2 days. Chronic lesions demonstrated preserved chordae without mitral regurgitation. Two targeted moderator bands were transmurally ablated without structural disruption. (2) Transatrial saline/carbon dioxide assisted epicardial access was obtained successfully and epicardial monopolar lesions had a mean length, width, and depth of 30.4±4.2, 23.5±4.1, and 9.1±1.9 mm, respectively. (3) Bipolar PFA lesions were delivered across the septum (n=11) and the left ventricular free wall (n=7). Twelve completed bipolar lesions had a mean length, width, and depth of 29.6±5.5, 21.0±7.3, and 14.3±4.7 mm, respectively. Chronically, these lesions demonstrated uniform fibrotic changes without tissue disruption. Bipolar lesions were significantly deeper than the monopolar epicardial lesions.
conclusionsThis in vivo evaluation demonstrates that PFA can successfully ablate intracavitary structures and create deep epicardial lesions and transmural left ventricular lesions.
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