Evidence map›Paper›PMID 38753510›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Essential role of N-terminal SAM regions in STIM1 multimerization and function.

Matthias Sallinger, Christina Humer, Hwei Ling Ong, Sasirekha Narayanasamy, Qi Tong Lin, Marc Fahrner, Herwig Grabmayr, Sascha Berlansky, Sean Choi, Tony Schmidt and 10 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening.Protein science : a publication of the Protein Society · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Matthias SallingerInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.ORCID 0000-0001-5225-8925
Christina HumerInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.ORCID 0009-0004-2636-7705
Hwei Ling OngSecretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.ORCID 0000-0002-7551-6883
Sasirekha NarayanasamySecretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.ORCID 0009-0008-5299-1906
Qi Tong LinDepartment of Physiology and Pharmacology, Western University, London, ON N6A5C1, Canada.ORCID 0000-0003-4636-6078
Marc FahrnerInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.ORCID 0000-0002-2689-0158
Herwig GrabmayrInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.ORCID 0000-0003-0870-5833
Sascha BerlanskyInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
Sean ChoiSecretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.ORCID 0009-0002-1328-9408
Tony SchmidtDepartment of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria.ORCID 0000-0001-8787-7363
Lena MaltanInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
Lara AtzgerstorferInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
Martin NiederwieserDepartment of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria.ORCID 0009-0000-4724-2849
Irene FrischaufInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.ORCID 0000-0003-0661-2932
Christoph RomaninInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.ORCID 0000-0003-3756-4136
Peter B StathopulosDepartment of Physiology and Pharmacology, Western University, London, ON N6A5C1, Canada.ORCID 0000-0002-0536-6656
Indu AmbudkarSecretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.ORCID 0000-0002-9559-8679
Romana LeitnerInstitute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.ORCID 0000-0002-9156-6266
Daniel BonhenryDepartment of Physics and Materials Science, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette L1511, Luxembourg.ORCID 0000-0002-6069-7642
Rainer SchindlDepartment of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria.ORCID 0000-0003-0896-8887

Funding

Molecular Mechanisms Regulating Calcium Flux In Salivary GlandsZIADE000438 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI AMBUDKAR, INDU S. · 2009 to 2025
$42.5M
Molecular Regulaton Calcium Flux In Salivary GlandsZ01DE000438 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI AMBUDKAR, INDU S. · 1987 to 2008
$3.6M
Austrian Science Fund (FWF) P32778Austrian Science Fund (FWF) P32947Austrian Science Fund (FWF) P33283Austrian Science Fund (FWF) P34884Austrian Science Fund (FWF) T1190-BCanadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) 05239Czech Science Foundation 19-20728YIntramural NIH HHS Z01 DE000438NIDCR-Division of Intramural Research Z01-DE00438-33
6 · The paper itself

Abstract

The single-pass transmembrane protein Stromal Interaction Molecule 1 (STIM1), located in the endoplasmic reticulum (ER) membrane, possesses two main functions: It senses the ER-Ca

Indexed as

Neoplasm ProteinsProtein MultimerizationStromal Interaction Molecule 1Binding SitesCalciumEndoplasmic ReticulumHEK293 CellsHumansMolecular Dynamics SimulationORAI1 ProteinProtein BindingProtein DomainsCalciumNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1EF-SAMOraiSOCESTIM

Identifiers

PMID38753510
PMCPMC11127010

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.