Evidence map›Paper›PMID 38753507›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in

Airi Nakayama, Masakatsu Watanabe, Riku Yamashiro, Hiroo Kuroyanagi, Hironori J Matsuyama, Atsunori Oshima, Ikue Mori, Shunji Nakano

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. A multilayered gap junction network is essential for social decision-making.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Aberrant neuronal hyperactivation causes an age-dependent behavioral decline inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Airi NakayamaDepartment of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, Japan.ORCID 0000-0002-9810-2106
Masakatsu WatanabeLaboratory of Pattern Formation, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan.ORCID 0000-0002-5744-197X
Riku YamashiroDepartment of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, Japan.
Hiroo KuroyanagiDepartment of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, Japan.
Hironori J MatsuyamaGroup of Molecular Neurobiology, Neuroscience Institute, Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, Japan.
Atsunori OshimaDepartment of Basic Biology, Cellular and Structural Physiology Institute, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
Ikue MoriGroup of Molecular Neurobiology, Neuroscience Institute, Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, Japan.
Shunji NakanoDepartment of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, Japan.ORCID 0000-0002-6565-9450

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
MEXT | Japan Science and Technology Agency (JST) JPMJSP2125MEXT | Japan Society for the Promotion of Science (JSPS) 18H05123MEXT | Japan Society for the Promotion of Science (JSPS) 19H05644MEXT | Japan Society for the Promotion of Science (JSPS) 21H052525MEXT | Japan Society for the Promotion of Science (JSPS) 23H02418NIH HHS P40 OD010440
6 · The paper itself

Abstract

While depolarization of the neuronal membrane is known to evoke the neurotransmitter release from synaptic vesicles, hyperpolarization is regarded as a resting state of chemical neurotransmission. Here, we report that hyperpolarizing neurons can actively signal neural information by employing undocked hemichannels. We show that UNC-7, a member of the innexin family in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsNeuronsSynaptic TransmissionAnimalsConnexinsInterneuronsMembrane ProteinsSynaptic VesiclesTaxis ResponseCaenorhabditis elegans ProteinsConnexinsMembrane ProteinsUnc-7 protein, C elegansC. eleganshemichannelinnexinneural communicationthermotaxis

Identifiers

PMID38753507
PMCPMC11127054

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.