Evidence map›Paper›PMID 38753288›Full record

ArticleEJNMMI research2024

Effect of radiation therapy on lymph node fluorescence in head and neck squamous cell carcinoma after intravenous injection of indocyanine green: a prospective evaluation.

Antoine Digonnet, Sophie Vankerkhove, Michel Moreau, Cécile Dekeyser, Marie Quiriny, Esther Willemse, Nicolas de Saint Aubain, Matteo Cappello, Vincent Donckier, Pierre Bourgeois

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antoine DigonnetDepartment of Head and Neck Surgery, Jules Bordet Institute, Université Libre de Bruxelles, 93 Rue Meylemeerch, Brussels, 1070, Belgium. antoine.digonnet@hubruxelles.be.
Sophie VankerkhoveDepartment of Surgical Oncology, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
Michel MoreauDepartment of Biostatistics, Jules Bordet institute, Université Libre de Bruxelles, Brussels, Belgium.
Cécile DekeyserDepartment of Head and Neck Surgery, Jules Bordet Institute, Université Libre de Bruxelles, 93 Rue Meylemeerch, Brussels, 1070, Belgium.
Marie QuirinyDepartment of Head and Neck Surgery, Jules Bordet Institute, Université Libre de Bruxelles, 93 Rue Meylemeerch, Brussels, 1070, Belgium.
Esther WillemseDepartment of Head and Neck Surgery, Jules Bordet Institute, Université Libre de Bruxelles, 93 Rue Meylemeerch, Brussels, 1070, Belgium.
Nicolas de Saint AubainDepartment of Pathology, Jules Bordet institute, Université Libre de Bruxelles, Brussels, Belgium.
Matteo CappelloDepartment of Thoracic Surgery, Academic Erasmus Hopsital, Université Libre de Bruxelles, Brussels, Belgium.
Vincent DonckierDepartment of Surgery, Jules Bordet institute, Université Libre de Bruxelles, Brussels, Belgium.
Pierre BourgeoisDepartment of Nuclear Medicine, Academic Erasmus Hopsital, Université Libre de Bruxelles, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndocyanine green (ICG)-guided surgery has proven effective in the identification of neoplastic tissues. The effect of radiation therapy (RT) on lymph node fluorescence after intravenous injection of ICG has not been addressed yet. The objective of this study was to evaluate the influence of RT on node fluorescence during neck dissection in head and neck squamous cell carcinoma (HNSCC).

resultsTwenty-four patients with planned neck dissection for HNSCC were prospectively enrolled. Eleven were included without previous radiation therapy and 13 after RT. ICG was intravenously administered in the operating room. The resected specimen was analyzed by the pathology department to determine the status of each resected lymph node (invaded or not). The fluorescence of each resected node was measured in arbitrary units (AU) on paraffin blocs. The surface area (mm

conclusionNo differences were observed between the fluorescence of irradiated and non-irradiated lymph nodes, including invaded nodes. ICG-guided surgery can be performed after failed RT.

trial registrationEudraCT ref. 2013-004498-29, registered 29 November 2013. https://www.clinicaltrialsregister.eu/ctr-search/search?query=2013-004498-29.

Indexed as

Head & neck squamous cell carcinomaICGRadiation therapy

Identifiers

PMID38753288
PMCPMC11098979

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.