Evidence map›Paper›PMID 38753244›Full record

ArticleEndocrine2024

Systolic blood pressure and risk of cardiovascular disease in normotensive diabetic adults: a prospective cohort study.

Yingting Zuo, Shuohua Chen, Xue Tian, Shouling Wu, Anxin Wang

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Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Yingting ZuoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Shuohua ChenDepartment of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China.
Xue TianDepartment of Epidemiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shouling WuDepartment of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China. drwusl@163.com.
Anxin WangDepartment of Epidemiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. wanganxin@bjtth.org.

Funding

Beijing Natural Science Foundation Haidian Original Innovation Joint Fund L222123High-level public health talents xuekegugan-02-47National Key Research and Development Program of China 2022YFC3600600Young Talents of Beijing Medical Management Center QML20230505
6 · The paper itself

Abstract

backgroundCurrently, the special blood pressure (BP) target for normotensive diabetic patients has not been recommended. We investigated the optimal systolic blood pressure (SBP) for lower cardiovascular disease (CVD) risk in normotensive diabetic patients.

methodsIn this 12-year follow-up study using the participants of the Kailuan Study, we mainly compared which SBP, 90-119 mmHg or 120-129 mmHg, had a lower risk of occurrence of CVD (stroke and myocardial infarction) in the 3072 normotensive diabetic participants and 21,532 normotensive and non-diabetic participants, respectively. The SBP was expressed as a mean time-weighted cumulative (MTWC) SBP, calculated from the multiple measurements of SBP during the follow-up. Multivariate competing risk regression analyses were used for the analysis.

resultsWe found that in normotensive diabetic participants, MTWC SBP of 120-129 mmHg was associated with a lower risk of CVD (HR = 0.69 [0.50-0.95]), myocardial infarction (HR = 0.48 [0.24-0.96]), and trending towards lower risk of stroke (HR = 0.80 [0.55-1.16]), compared to MTWC SBP of 90-119 mmHg. Sensitivity analyses confirmed the relationship between low SBP and increased CVD risk. Whereas, in the normotensive and non-diabetic participants, MTWC SBP of 90-119 mmHg vs 120-129 mmHg did not exhibit any difference in the risk of CVD occurrence (HR = 0.99 [0.83-1.18]).

conclusionsThe higher level of SBP in normotensive diabetic patients is especially associated with a lower risk of CVD occurrence.

Indexed as

Blood PressureCardiovascular DiseasesAdultAgedChinaDiabetes MellitusFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionProspective StudiesRisk FactorsStrokeDiabetesMyocardial infarctionProspective studyStrokeSystolic blood pressure

Identifiers

PMID38753244

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