Evidence map›Paper›PMID 38753241›Full record

ArticleDigestive diseases and sciences2024

Accuracy, Acceptability, and Application: Fecal Immunochemical Tests for Early Detection of Advanced Neoplasia in Colonoscopy-Based Surveillance.

Molla M Wassie, Maddison Dix, Geraldine Laven-Law, Norma Bulamu, Charles Cock, Peter Bampton, Robert J Fraser, Jean M Winter, Graeme P Young, Erin L Symonds

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In one paragraph

Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Molla M WassieFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia. molla.wassie@flinders.edu.au.
Maddison DixFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
Geraldine Laven-LawFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
Norma BulamuFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
Charles CockFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
Peter BamptonFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
Robert J FraserFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
Jean M WinterFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
Graeme P YoungFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.
Erin L SymondsFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia.

Funding

National Health and Medical Research Council 2009050
6 · The paper itself

Abstract

backgroundThe fecal immunochemical test (FIT) is widely used in colorectal cancer (CRC) screening, but limited data exist for its application in individuals at above-average risk for CRC who complete surveillance colonoscopies.

aimTo assess the accuracy, acceptability, and effectiveness of FIT in the interval between surveillance colonoscopies, for predicting advanced neoplasia (advanced adenoma or CRC) at the next colonoscopy.

methodsIndividuals enrolled in an Australian surveillance program were included. Diagnostic accuracy was determined for 614 individuals completing a two-sample FIT (OC-Sensor) ≤ 3 months preceding surveillance colonoscopy. 386 Individuals were surveyed to assess acceptability of interval FIT. Additionally, a retrospective analysis was performed on 7331 individuals offered interval FIT between colonoscopies, where a positive FIT (≥ 20 µg hemoglobin/g feces) triggered an early colonoscopy. Associations between interval FIT results and advanced neoplasia were determined using regression analysis.

resultsFIT detected CRC and advanced adenoma with sensitivities of 60.0% (3/5) and 27.1% (35/129), respectively. Most (89.1%, 344/386) survey respondents preferred completing interval FIT every 1-2 years. The detection rate of interval FIT for advanced neoplasia decreased with increasing FIT completion. Individuals returning a positive FIT had a higher risk of advanced neoplasia than those who did not complete FIT. Positive interval FIT reduced time-to-diagnosis for CRC and advanced adenoma by a median of 30 and 20 months, respectively.

conclusionInterval FIT was well accepted and enabled earlier detection of advanced neoplasia in individuals at above-average risk of CRC. Given that interval FIT predicts advanced neoplasia, it may be used to personalize surveillance colonoscopy intervals.

Indexed as

ColonoscopyColorectal NeoplasmsEarly Detection of CancerAdenomaAgedAustraliaFecesFemaleHumansMaleMiddle AgedOccult BloodPatient Acceptance of Health CareRetrospective StudiesAcceptabilityColonoscopyColorectal cancerDiagnostic accuracyFecal immunochemical testSurveillance

Identifiers

PMID38753241
PMCPMC11258152

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.