Evidence map›Paper›PMID 38753186›Full record

ReviewHistochemistry and cell biology2024

From feulgen to modern methods: marking a century of DNA imaging advances.

Melike Lakadamyali

Abstract readReviewHistorical Article
In one paragraph

Review in Histochemistry and cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Seeing genomes.Histochemistry and cell biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Melike LakadamyaliDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. melikel@pennmedicine.upenn.edu.

Funding

Research Project 2P50AR080581 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2023 to 2026
$7.9M
Single-cell dissection of chromatin architecture mechanisms connecting pathologic instability and transcriptional silencingU01DA052715 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI JAIN, RAJAN, JOYCE, ERIC F. · 2020 to 2024
$3.1M
Preserving chromatin nano-structure to enhance chondrocyte therapeutic potential for cartilage repairR01AR079224 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Su Chin Heo, Melike Lakadamyali · 2022 to 2026
$2.0M
Common Fund U01DA052715National Science Foundation CMMI-1548571NIAMS NIH HHS P50 AR080581NIAMS NIH HHS R01 AR079224NIDA NIH HHS U01 DA052715
6 · The paper itself

Abstract

The mystery of how human DNA is compactly packaged into a nucleus-a space a hundred thousand times smaller-while still allowing for the regulation of gene function, has long been one of the greatest enigmas in cell biology. This puzzle is gradually being solved, thanks in part to the advent of new technologies. Among these, innovative genome-labeling techniques combined with high-resolution imaging methods have been pivotal. These methods facilitate the visualization of DNA within intact nuclei and have significantly contributed to our current understanding of genome organization. This review will explore various labeling and imaging approaches that are revolutionizing our understanding of the three-dimensional organization of the genome, shedding light on the relationship between its structure and function.

Indexed as

DNAAnimalsHistory, 20th CenturyHistory, 21st CenturyHumansDNAAdvanced microscopyGenome labelingGenome organization

Identifiers

PMID38753186
PMCPMC11227465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.