Evidence map›Paper›PMID 38753016›Full record

SynthesisEuropean journal of applied physiology2024

Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status.

Gökhan İpekoğlu, Necdet Apaydın, Tuğba Çetin, Ahsen Nur Eren, Pelinsu Topçu, Büşra Yücelsoy, Güngör Civelek, Mert Sakar

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of applied physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gökhan İpekoğluFaculty of Sport Science, Ordu University, Ordu, Turkey.ORCID http://orcid.org/0000-0002-8530-0031
Necdet ApaydınFaculty of Sport Science, Ordu University, Ordu, Turkey.ORCID http://orcid.org/0000-0002-8930-3205
Tuğba ÇetinSchool of Physical Education and Sports, Karabuk University, Karabuk, Turkey. tugbacetin@karabuk.edu.tr.ORCID http://orcid.org/0000-0001-6117-8329
Ahsen Nur ErenFaculty of Sport Science, Ordu University, Ordu, Turkey.
Pelinsu TopçuFaculty of Sport Science, Ordu University, Ordu, Turkey.
Büşra YücelsoyFaculty of Sport Science, Ordu University, Ordu, Turkey.
Güngör CivelekFaculty of Sport Science, Ordu University, Ordu, Turkey.
Mert SakarFaculty of Sport Science, Ordu University, Ordu, Turkey.

Funding

Ordu Üniversitesi 0
6 · The paper itself

Abstract

purposeGenetic factors are important in terms of athletic performance. Recent studies to determine the relationship between the genes that lead to physiological responses have attracted attention. In this respect, this meta-analysis study was designed to examine the relationship between genetic polymorphism (BDKRB2 rs5810761, GNB3 rs5443, HIF1A rs11549565, MCT1 rs1049434, NOS3 rs2070744) and endurance athlete's status.

methodsThe search included studies published from 2009 to 2022. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned. Only case-control studies were included in the meta-analysis. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned, and a total of 31 studies met the criteria for inclusion in the meta-analysis. Relevant data from the included studies were collected and analyzed using a random effects or fixed effects model. The effect size was calculated as the odds ratio or a risk ratio the corresponding 95% confidence intervals.

resultsAccording to the results of the analysis, BDKRB2 rs5810761 + 9 allele, and NOS3 rs2070744 T allele were significantly more prevalent in endurance athletes (p < 0.05). Genotype distributions of BDKRB2 rs5810761, MCT1 rs1049434, and NOS3 rs2070744 showed significant differences in the dominant model (p < 0.05). However, no significant association was found between endurance athlete status and GNB3 rs5443 and HIF1A rs11549465 polymorphisms.

conclusionThese results show that some gene polymorphisms play an important role in endurance athlete status and suggest that having a specific genetic basis may also confer a physiological advantage for performance.

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitMonocarboxylic Acid TransportersPhysical EndurancePolymorphism, Single NucleotideSymportersAthletesAthletic PerformanceHeterotrimeric GTP-Binding ProteinsHumansMonocarboxylate Transport Protein 1Nitric Oxide Synthase Type IIIReceptors, G-Protein-CoupledGNB3 protein, humanHeterotrimeric GTP-Binding ProteinsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersNitric Oxide Synthase Type IIINOS3 protein, humanReceptors, G-Protein-CoupledSymportersBDKRB2Genetic polymorphismGNB3HIF1AMCT1NOS3

Identifiers

PMID38753016
PMCPMC11199302

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.