Evidence map›Paper›PMID 38752952›Full record

ArticleJACC. Clinical electrophysiology2024

Conduction Velocity and Anisotropic Properties of Fibrillation Waves During Acutely Induced and Long-Standing Persistent AF.

Mathijs S van Schie, Shmaila Talib, Paul Knops, Yannick J H J Taverne, Natasja M S de Groot

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Article in JACC. Clinical electrophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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3 · Its place in the literature

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5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mathijs S van SchieDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Shmaila TalibDepartment of Cardiology, Haga Teaching Hospital, The Hague, the Netherlands.
Paul KnopsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Yannick J H J TaverneDepartment of Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
Natasja M S de GrootDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Microelectronics, Delft University of Technology, Delft, the Netherlands. Electronic address: n.m.s.degroot@erasmusmc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuantified features of local conduction heterogeneity due to pathological alterations of myocardial tissue could serve as a marker for the degree of electrical remodeling and hence be used to determine the stage of atrial fibrillation (AF).

objectivesIn this study, the authors investigated whether local directional heterogeneity (LDH) and anisotropy ratio, derived from estimated local conduction velocities (CVs) during AF, are suitable electrical parameters to stage AF.

methodsEpicardial mapping (244-electrode array, interelectrode distance 2.25 mm) of the right atrium was performed during acute atrial fibrillation (AAF) (n = 25, 32 ± 11 years of age) and during long-standing persistent atrial fibrillation (LSPAF) (n = 23, 64 ± 9 years of age). Episodes of 9 ± 4 seconds of AF were analyzed. Local CV vectors were constructed to assess the degree of anisotropy. Directions and magnitudes of individual vectors were compared with surrounding vectors to identify LDH.

resultsCompared with the entire AAF group, LSPAF was characterized by slower conduction (71.5 ± 6.8 cm/s vs 67.6 ± 5.6 cm/s; P = 0.037) with a larger dispersion (1.59 ± 0.21 vs 1.95 ± 0.17; P < 0.001) and temporal variability (32.0 ± 4.7 cm/s vs 38.5 ± 3.3 cm/s; P < 0.001). Also, LSPAF was characterized by more LDH (19.6% ± 4.4% vs 26.0% ± 3.4%; P < 0.001) and a higher degree of anisotropy (1.38 ± 0.07 vs 1.51 ± 0.14; P < 0.001). Compared with the most complex type of AAF (type III), LSPAF was still associated with a larger CV dispersion, higher temporal variability of CV, and larger amount of LDH.

conclusionsIncreasing AF complexity was associated with increased spatiotemporal variability of local CV vectors, local conduction heterogeneity, and anisotropy ratio. By using these novel parameters, LSPAF could potentially be discriminated from the most complex type of AAF. These observations may indicate pathological alterations of myocardial tissue underlying progression of AF.

Indexed as

Atrial FibrillationHeart Conduction SystemAdultAgedAnisotropyEpicardial MappingFemaleHeart AtriaHumansMaleMiddle Agedanisotropyatrial fibrillationconduction disordersconduction heterogeneityelectrophysiologyhigh-resolution epicardial mappinginduced atrial fibrillationlong-standing persistent atrial fibrillationremodeling

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PMID38752952

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