Evidence map›Paper›PMID 38752903›Full record

ArticleCell cycle (Georgetown, Tex.)2024

UHRF2 accumulates in early G

Xiaohong Wang, Huarui Lu, Grace Sprangers, Timothy C Hallstrom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaohong WangDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.
Huarui LuDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.
Grace SprangersDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.
Timothy C HallstromDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.

Funding

Cell Fate Control by Integrated E2F, FoxO and PI3K Signaling in RetinoblastomaR01CA168622 · NCI · UNIVERSITY OF MINNESOTA · PI HALLSTROM, TIMOTHY C. · 2013 to 2017
$1.6M
NCI NIH HHS R01 CA168622
6 · The paper itself

Abstract

Ubiquitin like with PHD and ring finger domains 2 (UHRF2) regulates the cell cycle and epigenetics as a multi-domain protein sharing homology with UHRF1. UHRF1 functions with DNMT1 to coordinate daughter strand methylation during DNA replication, but UHRF2 can't perform this function, and its roles during cell cycle progression are not well defined. UHRF2 role as an oncogene vs. tumor suppressor differs in distinct cell types. UHRF2 interacts with E2F1 to control Cyclin E1 (

Indexed as

Cyclin EG1 PhaseMitosisUbiquitin-Protein LigasesCell CycleCyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p27HumansOncogene ProteinsPhosphorylationCCNE1 protein, humanCyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p27Cyclin EOncogene ProteinsUbiquitin-Protein LigasesUHRF2 protein, humancell cyclecyclin/CdkFUCCIUHRF2

Identifiers

PMID38752903
PMCPMC11135863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.