Evidence map›Paper›PMID 38752835›Full record

ArticleeLife2024

Remodeling of skeletal muscle myosin metabolic states in hibernating mammals.

Christopher T A Lewis, Elise G Melhedegaard, Marija M Ognjanovic, Mathilde S Olsen, Jenni Laitila, Robert A E Seaborne, Magnus Gronset, Changxin Zhang, Hiroyuki Iwamoto, Anthony L Hessel and 13 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Bed rest decreases resting skeletal muscle OExperimental physiology · 2026
    Article
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  4. Review
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  7. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Christopher T A LewisDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-4477-422X
Elise G MelhedegaardDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marija M OgnjanovicDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mathilde S OlsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jenni LaitilaDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Robert A E SeaborneDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Magnus GronsetDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Changxin ZhangDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, United States.
Hiroyuki IwamotoSpring-8, Japan Synchrotron Radiation Research Institute, Hyogo, Japan.
Anthony L HesselInstitute of Physiology II, University of Muenster, Muenster, Germany.
Michel N KuehnInstitute of Physiology II, University of Muenster, Muenster, Germany.
Carla MerinoBiosfer Teslab, Reus, Spain.
Nuria AmigoBiosfer Teslab, Reus, Spain.
Ole FrobertDepartment of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
Sylvain GiroudEnergetics Lab, Department of Biology, Northern Michigan University, Marquette, United States.ORCID https://orcid.org/0000-0001-6621-7462
James F StaplesDepartment of Biology, University of Western Ontario, London, Canada.
Anna V GoropashnayaCenter for Transformative Research in Metabolism, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, United States.
Vadim B FedorovCenter for Transformative Research in Metabolism, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, United States.
Brian BarnesCenter for Transformative Research in Metabolism, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, United States.
Oivind ToienCenter for Transformative Research in Metabolism, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, United States.ORCID https://orcid.org/0000-0001-5967-2483
Kelly DrewCenter for Transformative Research in Metabolism, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, United States.
Ryan J SprengerDepartment of Zoology, University of British Columbia, Vancouver, Canada.
Julien OchalaDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Funding

Renovation of LARS for Arctic Ground Squirrel BreedingP20GM130443 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI KELLY L DREW · 2019 to 2026
$16.4M
Carlsbergfondet CF20-0113NIGMS NIH HHS P20 GM130443Norwegian Environment Agency and the Swedish Environmental Protection Agency P20GM130443Novo Nordisk Foundation NNF19SA0059305
6 · The paper itself

Abstract

Hibernation is a period of metabolic suppression utilized by many small and large mammal species to survive during winter periods. As the underlying cellular and molecular mechanisms remain incompletely understood, our study aimed to determine whether skeletal muscle myosin and its metabolic efficiency undergo alterations during hibernation to optimize energy utilization. We isolated muscle fibers from small hibernators,

Indexed as

HibernationAdenosine TriphosphateAnimalsEnergy MetabolismMuscle Fibers, SkeletalMuscle, SkeletalProteomicsSkeletal Muscle MyosinsUrsidaeAdenosine TriphosphateSkeletal Muscle Myosinsbiochemistrycell biologychemical biologyeliomys quercinusictidomys tridecemlineatusursus americanusursus arctos

Identifiers

PMID38752835
PMCPMC11098559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.