Evidence map›Paper›PMID 38752731›Full record

ArticleMicrobiology spectrum2024

Enterovirus A71 crosses a human blood-brain barrier model through infected immune cells.

Léa Gaume, Hélène Chabrolles, Maxime Bisseux, Igor Lopez-Coqueiro, Lucie Dehouck, Audrey Mirand, Cécile Henquell, Fabien Gosselet, Christine Archimbaud, Jean-Luc Bailly

Erratum issuedAbstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Léa GaumeLaboratoire Microorganismes: Génome et Environnement (LMGE), CNRS UMR 6023, Clermont Auvergne Université, Clermont-Ferrand, France.ORCID 0009-0007-9406-7538
Hélène ChabrollesLaboratoire Microorganismes: Génome et Environnement (LMGE), CNRS UMR 6023, Clermont Auvergne Université, Clermont-Ferrand, France.ORCID 0000-0001-8038-2130
Maxime BisseuxLaboratoire Microorganismes: Génome et Environnement (LMGE), CNRS UMR 6023, Clermont Auvergne Université, Clermont-Ferrand, France.ORCID 0000-0002-3489-049X
Igor Lopez-CoqueiroLaboratoire Microorganismes: Génome et Environnement (LMGE), CNRS UMR 6023, Clermont Auvergne Université, Clermont-Ferrand, France.
Lucie DehouckLaboratoire de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois, Lens, France.
Audrey MirandLaboratoire Microorganismes: Génome et Environnement (LMGE), CNRS UMR 6023, Clermont Auvergne Université, Clermont-Ferrand, France.
Cécile HenquellLaboratoire Microorganismes: Génome et Environnement (LMGE), CNRS UMR 6023, Clermont Auvergne Université, Clermont-Ferrand, France.ORCID 0000-0003-2859-6566
Fabien GosseletLaboratoire de la Barrière Hémato-Encéphalique (LBHE), Université d'Artois, Lens, France.ORCID 0000-0002-0481-5026
Christine ArchimbaudLaboratoire Microorganismes: Génome et Environnement (LMGE), CNRS UMR 6023, Clermont Auvergne Université, Clermont-Ferrand, France.ORCID 0000-0001-7665-5618
Jean-Luc BaillyLaboratoire Microorganismes: Génome et Environnement (LMGE), CNRS UMR 6023, Clermont Auvergne Université, Clermont-Ferrand, France.ORCID 0000-0002-9770-6450

Funding

EC | Horizon 2020 Framework Programme (H2020) OrganoVIR Grant 812673
6 · The paper itself

Abstract

Enterovirus A71 (EV-A71) is associated with neurological conditions such as acute meningitis and encephalitis. The virus is detected in the bloodstream, and high blood viral loads are associated with central nervous system (CNS) manifestations. We used an

Indexed as

Blood-Brain BarrierEndothelial CellsEnterovirus A, HumanEnterovirus InfectionsBrainHumansKiller Cells, NaturalLeukocytesMonocytesNeutrophilsPericytesVirus ReplicationBBB crossingblood–brain barrier modelEV-A71 neurotropismneuroinvasionwhite blood cells

Identifiers

PMID38752731
PMCPMC11237604

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.