Evidence map›Paper›PMID 38752642›Full record

ArticleCombinatorial chemistry & high throughput screening2025

Proteomics Approach to Identify Serum Biomarkers Associated with Gastric Cancer in South Indian Tamils.

Jeevitha Chithra Madhesh, Manojkumar Narasiman, Vignesh Nagarajan, S Meenalosani, Sweta Varshikaa, Ananthi Sivagnanam, Megala Jayaraman

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Article in Combinatorial chemistry & high throughput screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Jeevitha Chithra MadheshDepartment of Genetic Engineering, Faculty of Science and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai-603203, Tamilnadu, India.ORCID 0000-0002-5127-1455
Manojkumar NarasimanDepartment of Genetic Engineering, Faculty of Science and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai-603203, Tamilnadu, India.ORCID 0000-0002-3794-1416
Vignesh NagarajanDepartment of Genetic Engineering, Faculty of Science and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai-603203, Tamilnadu, India.
S MeenalosaniProteomics Department, Clinbiocare Technology, Tenkasi 627814, India.
Sweta VarshikaaProteomics Department, Clinbiocare Technology, Tenkasi 627814, India.
Ananthi SivagnanamProteomics Department, Clinbiocare Technology, Tenkasi 627814, India.
Megala JayaramanDepartment of Genetic Engineering, Faculty of Science and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai-603203, Tamilnadu, India.ORCID 0000-0001-5246-4104

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentifying cancer-specific biomarkers is a crucial step in the disease screening process at a very early stage of tumor development. In recent years, Quantitative proteomic approaches have gained importance in identifying novel candidate markers in cancer. Gastric cancer has always been known as a life-threatening medical condition with high mortality rates.

objectivesThe objective of our research is to adapt serum samples from Indian gastric cancer patients to identify and understand the differentially regulated proteins in comparison with healthy individuals.

methodsA total of 30 serum isolates from gastric cancer patients and healthy individuals were obtained and subjected to 2-D Gel electrophoresis, and Tandem LC-MS analysis revealed 12 differentially expressed protein spots. The functional properties of identified proteins were further analyzed using PANTHER and STRING databases.

resultsThe differentially expressed protein spots were identified as three candidate proteins: Haptoglobin, Prohibitin, and Apolipoprotein. The protein interaction studies reveal that the haptoglobin fragments were upregulated, and the remaining two prohibitin and Apolipoprotein were down-regulated in gastric cancer patients.

conclusionAll the proteins identified as biomarkers were found to be involved in regulating cell proliferation and stabilization of oxidative metabolism in the liver; therefore, differential regulation plays a crucial role in gastric cancer progression.

Indexed as

Biomarkers, TumorProteomicsStomach NeoplasmsFemaleHumansIndiaMaleMiddle AgedProhibitinsBiomarkers, TumorProhibitins2-D gel.biomarkergastric cancerLC-MSProhibitinproteomics

Identifiers

PMID38752642

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