Evidence map›Paper›PMID 38752471›Full record

ArticleMolecular pain

Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression.

Robin Vroman, Shingo Ishihara, Spencer Fullam, Matthew J Wood, Natalie S Adamczyk, Nolan Lomeli, Fransiska Malfait, Anne-Marie Malfait, Rachel E Miller, Adrienn Markovics

Abstract read
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robin VromanDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Shingo IshiharaDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Spencer FullamDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Matthew J WoodDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Natalie S AdamczykDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Nolan LomeliDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Fransiska MalfaitDepartment of Biomolecular Medicine, Center for Medical Genetics, Ghent University, Ghent, Belgium.
Anne-Marie MalfaitDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Rachel E MillerDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Adrienn MarkovicsDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0003-4913-845X

Funding

Osteoarthritis Progression And Sensory Pathway AlterationsR01AR064251 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI MALFAIT, ANNE-MARIE, MILLER, RICHARD J · 2013 to 2025
$7.6M
Molecular Pathways of Pain Generation in OsteoarthritisR01AR060364 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI MALFAIT, ANNE-MARIE · 2011 to 2025
$6.0M
Neurobiology Core CP30AR079206 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Anne-Marie Malfait · 2021 to 2026
$4.7M
The Role of Mechanosensation Pathways in Osteoarthritis Joint Damage and PainR01AR077019 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Rachel Elizabeth Miller · 2021 to 2026
$2.7M
NIAMS NIH HHS P30 AR079206NIAMS NIH HHS R01 AR060364NIAMS NIH HHS R01 AR064251NIAMS NIH HHS R01 AR077019
6 · The paper itself

Abstract

Transient Receptor Potential Vanilloid 1 (TRPV1) is a nonselective cation channel expressed by pain-sensing neurons and has been an attractive target for the development of drugs to treat pain. Recently, Src homology region two domain-containing phosphatase-1 (SHP-1, encoded by

Indexed as

CapsaicinGanglia, SpinalHyperalgesiaProtein Tyrosine Phosphatase, Non-Receptor Type 6TRPV Cation ChannelsAnimalsCalciumFemaleMaleMiceMice, TransgenicNeuronsSensory Receptor CellsCalciumCapsaicinProtein Tyrosine Phosphatase, Non-Receptor Type 6TRPV1 protein, mouseTRPV Cation Channelscapsaicinnociceptorspainsrc homology region 2 domain-containing phosphatase 1transient receptor potential vanilloid 1

Identifiers

PMID38752471
PMCPMC11273697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.