Evidence map›Paper›PMID 38752345›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Placental Methylglyoxal in Preeclampsia: Vascular and Biomarker Implications.

Philippe Vangrieken, Salwan Al-Nasiry, Alex H V Remels, Paul M H Schiffers, Emma Janssen, Stefanie Nass, Jean L J M Scheijen, Marc E A Spaanderman, Casper G Schalkwijk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Philippe VangriekenSchool for Cardiovascular Diseases, Department of Internal Medicine (P.V., S.N., J.L.J.M.S., C.G.S.), Maastricht University Medical Center+, the Netherlands.
Salwan Al-NasirySchool for Oncology and Developmental Biology, Department of Obstetrics and Gynaecology (S.A.-N., E.J., M.E.A.S.), Maastricht University Medical Center+, the Netherlands.ORCID 0000-0003-0268-2095
Alex H V RemelsSchool of Nutrition and Translational Research in Metabolism, Department of Pharmacology and Toxicology (A.H.V.R.), Maastricht University Medical Center+, the Netherlands.
Paul M H SchiffersSchool for Cardiovascular Diseases, Department of Pharmacology and Toxicology (P.M.H.S.), Maastricht University Medical Center+, the Netherlands.
Emma JanssenSchool for Oncology and Developmental Biology, Department of Obstetrics and Gynaecology (S.A.-N., E.J., M.E.A.S.), Maastricht University Medical Center+, the Netherlands.ORCID 0000-0001-6916-7261
Stefanie NassSchool for Cardiovascular Diseases, Department of Internal Medicine (P.V., S.N., J.L.J.M.S., C.G.S.), Maastricht University Medical Center+, the Netherlands.ORCID 0009-0003-3169-5802
Jean L J M ScheijenSchool for Cardiovascular Diseases, Department of Internal Medicine (P.V., S.N., J.L.J.M.S., C.G.S.), Maastricht University Medical Center+, the Netherlands.ORCID 0000-0002-1268-2286
Marc E A SpaandermanSchool for Oncology and Developmental Biology, Department of Obstetrics and Gynaecology (S.A.-N., E.J., M.E.A.S.), Maastricht University Medical Center+, the Netherlands.
Casper G SchalkwijkSchool for Cardiovascular Diseases, Department of Internal Medicine (P.V., S.N., J.L.J.M.S., C.G.S.), Maastricht University Medical Center+, the Netherlands.ORCID 0000-0003-0190-2690

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreeclampsia is a multifaceted syndrome that includes maternal vascular dysfunction. We hypothesize that increased placental glycolysis and hypoxia in preeclampsia lead to increased levels of methylglyoxal (MGO), consequently causing vascular dysfunction.

methodsPlasma samples and placentas were collected from uncomplicated and preeclampsia pregnancies. Uncomplicated placentas and trophoblast cells (BeWo) were exposed to hypoxia. The reactive dicarbonyl MGO and advanced glycation end products (N

resultsMGO, CML, CEL, and MG-H2 levels were elevated in preeclampsia-placentas (+36%, +36%, +25%, and +22%, respectively). Reduced GLO1 activity was observed in preeclampsia-placentas (-12%) and hypoxia-exposed placentas (-16%). Hypoxia-induced MGO accumulation in placentas was mitigated by the MGO-quencher quercetin. Trophoblast cells were identified as the primary source of MGO. Reduced GLO1 activity was also observed in hypoxia-exposed BeWo cells (-26%). Maternal plasma concentrations of CML and the MGO-derived MG-H1 increased as early as 12 weeks of gestation (+16% and +17%, respectively). MGO impaired endothelial barrier function, an effect mitigated by MitoQ, and heightened vascular responsiveness to thromboxane A2.

conclusionsThis study reveals the accumulation of placental MGO in preeclampsia and upon exposure to hypoxia, demonstrates how MGO can contribute to vascular impairment, and highlights plasma CML and MG-H1 levels as promising early biomarkers for preeclampsia.

Indexed as

BiomarkersPlacentaPre-EclampsiaPyruvaldehydeAdultFemaleGlycation End Products, AdvancedHumansLactoylglutathione LyasePregnancyTrophoblastsBiomarkersGLO1 protein, humanGlycation End Products, AdvancedLactoylglutathione LyasePyruvaldehydebiomarkersglycation end products, advancedhypertensionmethylglyoxalpreeclampsiatrophoblastsvascular dysfunction

Identifiers

PMID38752345
PMCPMC11208051

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.