Evidence map›Paper›PMID 38752121›Full record

ArticleFood science and biotechnology2024

Enrichment of C17:0-rich saturated fatty acids from sheep tail fat for adjuvant therapy of non-small-cell lung cancer.

Xiaoqi Yu, Xiaoyi Liu, Yuanli Li, Huimin He, Xinxin Pei, Tengfei Ma, Yuanyuan Chen, Yi Wang, Hongxia Li, Wenchu Lin and 2 more

Abstract read
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In one paragraph

Article in Food science and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Xiaoqi Yu *Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601 Anhui People's Republic of China.
Xiaoyi Liu *Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601 Anhui People's Republic of China.
Yuanli Li *Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601 Anhui People's Republic of China.
Huimin HeInstitutes of Physical Science and Information Technology, Anhui University, Hefei, 230601 Anhui People's Republic of China.
Xinxin PeiInstitutes of Physical Science and Information Technology, Anhui University, Hefei, 230601 Anhui People's Republic of China.
Tengfei MaAnhui Tianxiang Grain and Oil Food Co., Ltd., Fuyang, 230600 Anhui People's Republic of China.
Yuanyuan ChenSchool of Life Sciences, Anhui University, Hefei, Anhui 230601 People's Republic of China.
Yi WangDepartment of Oncology, The Third Affiliated Hospital of Anhui Medical University, Hefei, 230601 People's Republic of China.
Hongxia LiDepartment of Oncology, The Third Affiliated Hospital of Anhui Medical University, Hefei, 230601 People's Republic of China.
Wenchu LinHigh Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui China.
Changzhi XuInstitutes of Physical Science and Information Technology, Anhui University, Hefei, 230601 Anhui People's Republic of China.ORCID 0000-0002-8769-3983
Buchang ZhangInstitutes of Physical Science and Information Technology, Anhui University, Hefei, 230601 Anhui People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heptadecanoic acid (C17:0), an odd-chain saturated fatty acid (OCSFA) in ruminant lipid, has been demonstrated to be potential for treating cancers. Our results also showed that sheep tail fat (STF) with higher level of C17:0-containing saturated fatty acids (SFAs) whereas lower level of oleic acid (C18:1), performed remarkable inhibition against non-small-cell lung cancer (NSCLC) cells. To enrich the content of C17:0, a C17:0-rich SFA concentrate (HRSC) was prepared from STF by solvent crystallization and urea complexation methods (hexane/STF = 3.5/1, 4 °C for 8 h, and 80% ethanol/urea/free fatty acids = 8/1/1, 4 °C for 6 h). The content of C17:0 was up from 3.02 to 6.34% and the recovery was 4.17%. Biological experiments showed that HRSC exerted better antiproliferative effect against NSCLC cells. Moreover, HRSC performed enhanced inhibitory effect in A549 cell xenograft mouse model. Therefore, HRSC has the potential to be applied in adjuvant therapy for NSCLC. Supplementary Information: The online version contains supplementary material available at 10.1007/s10068-023-01504-w.

Indexed as

Heptadecanoic acidOdd-chain saturated fatty acidSheep tail fatSolvent crystallizationUrea complexation

Identifiers

PMID38752121
PMCPMC11091029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.