ArticleFrontiers in medicine2024
Collagen peptides affect collagen synthesis and the expression of collagen, elastin, and versican genes in cultured human dermal fibroblasts.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07516756 (Impact of Oral Supplementation of Specific Bioactive Collagen Peptides on Human Skin Physiology), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Oral Supplementation of Specific Bioactive Collagen Peptides on Human Skin Physiology: A Randomized, Double-Blind, Placebo-Controlled Trial
Who cites it
15 citing papers in PubMed.
- Liposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial.Journal of cosmetic dermatology · 2026Trial
- A novel all-in-one dynamic wrinkle evaluation system: Development, validation and application in cosmetic industries.International journal of cosmetic science · 2026Article
- Low-Molecular-Weight Salmon Collagen Peptides Promote Extracellular Matrix Gene (ECM) Expression in BJ Fibroblasts.International journal of molecular sciences · 2026Article
- Research Progress on Bioactive Peptides From Diverse Sources: Preparation, Structure-Activity Relationship, and Applications.Journal of food science · 2026Review
- Article
- Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.Nutrients · 2026Review
- Integrative Dermatology for Longevity: The Synergy of Topical and Internal Approaches.Dermatology and therapy · 2026Review
- Gingival Thickness Improvement After Atelocollagen Injection-Retrospective Study.Life (Basel, Switzerland) · 2026Article
- Specific collagen peptides supplementation increases collagen type I content in skeletal muscle after 12 weeks of high-load resistance training: a randomized controlled trial.Frontiers in physiology · 2026Article
- Non-Surgical Correction of Facial Asymmetry: A Narrative Review of Non-Surgical Modalities and Clinical Case Examples.Journal of clinical medicine · 2025Review
- In Vitro Bioactivity of a Recombinant Human Collagen Peptide in a Filler Biomimetic Skin Model.Journal of cosmetic dermatology · 2025Article
- Effect of a chondroitin sulfate chain linked to the bikunin core peptide on gene expression in lipopolysaccharide-treated uterine cervical fibroblasts.Biochemistry and biophysics reports · 2025Article
- Cellular and Molecular Mechanisms of Wound Repair: From Biology to Therapeutic Innovation.Cells · 2025Review
- Targeting Dermal Fibroblast Senescence: From Cellular Plasticity to Anti-Aging Therapies.Biomedicines · 2025Review
- Immune Dysregulation and Cellular Composition in Lichen Sclerosus Revealed by Integrative Epigenetic Analysis with Cell Type Deconvolution.Journal of inflammation research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Collagen is one of the major proteins of the skin and it is particularly important for its strength and resilience. Skin aging is a natural process that is characterized by the decrease and fragmentation of collagen in the dermis. Oral supplementation with collagen peptides has been clinically shown to have a positive effect on the skin condition. However, the mechanisms of aging-related changes synthesized by cells exposed to collagen are currently not well understood. Therefore, in this Methods: The effects of different concentrations of collagen peptides on cell viability and metabolism were analyzed. For gene expression analysis, human dermal fibroblasts were treated with collagen peptides. This was then followed by RNA extraction and DNA synthesis. Gene expressions of collagen type 1 (COL1A1), elastin (ELN), and versican (VCAN) were quantified by quantitative reverse transcription polymerase chain reaction (RT-qPCR). In addition, collagen levels were analyzed by confocal scanning laser microscopy using immunostaining. Results: Collagen peptides tested in the study increased the expression of the relevant COL1A1, ELN, and VCAN genes in human dermal fibroblasts ( Conclusion: These data provide cell-based evidence for the beneficial effects of exposure to collagen peptides on the skin's collagen content and on the molecules that provide firmness and elasticity. This may support the hypothesis that collagen peptides are important for maintaining extracellular matrix (ECM) structure and skin regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.