ArticleOpen forum infectious diseases2024
Infectious Mediastinitis: A Retrospective Cohort Study.
Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Descending Necrotizing Mediastinitis Across Age and Host-Status Groups: Diagnosis, Treatment Phases, and Outcomes in the Literature, with an Illustrative Case.Infectious diseases and therapy · 2026Pooled it
- A bibliometric analysis of research trends in mediastinitis: a rare, high mortality, and complex infectious disease.Journal of thoracic disease · 2026Article
- Endoscopic transcervical mediastinal drainage for treating descending necrotizing mediastinitis.BMC surgery · 2026Observational
- Treatment of the infection in deep sternal wound infections-a single center cohort study.Journal of thoracic disease · 2026Article
- Descending Necrotizing Mediastinitis, When Mediastinal Drainage By Thoracoscopy Is Not Sufficient: Case Report and Review of the Literature.Clinical medicine insights. Case reports · 2026Article
- Mediastinitis after cardiac surgery, from microbes to management: a systematic review.Mediastinum (Hong Kong, China) · 2026Review
- Mediastinal infections: diagnostic and therapeutic advances from traditional surgery to novel minimally invasive techniques.Frontiers in medicine · 2025Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aimed to characterize the demographics, microbiology, management and treatment outcomes of mediastinitis according to the origin of the infection. Methods: This retrospective observational study enrolled patients who had mediastinitis diagnosed according to the criteria defined by the Centers for Disease Control and Prevention and were treated in Strasbourg University Hospital, France, between 1 January 2010 and 31 December 2020. Results: We investigated 151 cases, including 63 cases of poststernotomy mediastinitis (PSM), 60 cases of mediastinitis due to esophageal perforation (MEP) and 17 cases of descending necrotizing mediastinitis (DNM). The mean patient age (standard deviation) was 63 (14.5) years, and 109 of 151 patients were male. Microbiological documentation varied according to the origin of the infection. When documented, PSM cases were mostly monomicrobial (36 of 53 cases [67.9%]) and involved staphylococci (36 of 53 [67.9%]), whereas MEP and DNM cases were mostly plurimicrobial (38 of 48 [79.2%] and 8 of 12 [66.7%], respectively) and involved digestive or oral flora microorganisms, respectively. The median duration of anti-infective treatment was 41 days (interquartile range, 21-56 days), and 122 of 151 patients (80.8%) benefited from early surgical management. The overall 1-year survival rate was estimated to be 64.8% (95% confidence interval, 56.6%-74.3%), but varied from 80.1% for DNM to 61.5% for MEP. Conclusions: Mediastinitis represents a rare yet deadly infection. The present cohort study exhibited the different patterns observed according to the origin of the infection. Greater insight and knowledge on these differences may help guide the management of these complex infections, especially with respect to empirical anti-infective treatments.
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